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Sunday, January 6, 2013

Study: Heart Attack Patients Receive High Dose of Radiation

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MONDAY, Nov. 16, 2009 (Health.com) — Heart attack patients are exposed to a radiation dose equal to about 725 chest X-rays over the course of their hospital stay, according to research presented Monday at the American Heart Association meeting in Orlando. The radiation comes from tests such as computed tomography (CT) scans, cardiac catheterizations, and artery-clearing angioplasties.

Too much radiation can increase the risk of developing some cancers, although the benefits of such tests typically outweigh the risks when it comes to diagnosing and treating heart attacks. The cancer risk associated with an angioplasty or with a CT scan—which delivers about 500 times more radiation than an X-ray—is hard to measure.

Prashant Kaul, MD, the lead study author and a cardiovascular fellow at Duke University Medical Center, in Durham, N.C., stresses that many cardiac tests that use radiation are necessary and appropriate.

"We’re not saying those should be withheld," he says. "We're just trying to increase awareness so that when physicians are ordering tests, they bear in mind the indications.”

The study, which was conducted over three and a half years, included nearly 65,000 heart attack hospitalizations at 49 academic hospitals across the United States. The researchers estimated radiation doses by looking at hospital records; they didn’t measure exposure directly.

A single radiation-delivering test generally poses little cancer risk, but the heart attack patients in the study averaged about four such tests during their hospital stay, potentially multiplying the risk.

Angioplasty (also known as percutaneous coronary intervention, or PCI), a procedure in which a balloon-tipped catheter is used to open a blocked artery, delivers a dose of radiation about 750 times greater than an X-ray, but that doesn’t mean doctors shouldn't perform it, says Dr. Kaul.

“No one would argue that you shouldn’t do that—it’s a lifesaving procedure,” he says.

Thomas C. Gerber, MD, PhD, a professor of medicine and radiology at the Mayo Clinic’s College of Medicine, in Jacksonville, Fla., says "it’s difficult to assess the health risk of ionizing radiation.”

It’s unclear if there’s a risk associated with a radiation dose less than 100 millisieverts, which is an amount of radiation about seven times greater than the average dose seen in the study, says Dr. Gerber.

“If there's an increased risk of cancer, it’s small, and nobody’s been able to show it,” says Dr. Gerber, who has studied radiation safety in medical testing but was not involved in the study.

The patients in the study were exposed to about 14.5 millisieverts, a dose roughly five times greater than the amount of exposure from so-called background radiation in the environment.

The U.S. Food and Drug Administration (FDA) has estimated that the amount of radiation absorbed by the body during a CT scan increases the lifetime risk of dying of cancer by a factor of 1 in 2000. The natural risk of dying from cancer is about 1 in 5, so the added risk posed by the radiation is very small.

According to the FDA, the benefits of a CT scan generally outweigh the risks for those with a medical need, but not for symptomless people who are considering a CT scan only for screening purposes.

According to Dr. Kaul, physicians should take into account a patient's total radiation exposure during a hospital stay, rather than the dose from one individual test.

Exposure to radiation during occasional tests is safer than a relatively large dose in a short period of time, experts say.

“Having 17 millisieverts in January and another 17 millisieverts in October isn’t the same as having 34 millisieverts all at the same time,” says Dr. Gerber. “Small amounts of radiation in certain increments don’t mean the same as one large dose of radiation at the same time.”

Patients shouldn’t be afraid to ask their doctor if a test is truly necessary, he says. “There's nothing wrong with patients asking their doctor, ‘How will this test change what you do for me?’ If it doesn’t, that test may not be necessary.”

Heart attack patients shouldn't forgo a test simply because of concerns about radiation, says Dr. Kaul. Doing so could prevent doctors from diagnosing a dangerous problem or treating a patient to the best of their ability.

“We don’t want to scare people into thinking they’re going into the hospital and their risk of cancer’s going to suddenly increase,” says Dr. Kaul. “It’s a balance between the hypothetical risk of cancer with the risks of not performing an imaging study."

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Saturday, January 5, 2013

Coronary Artery Disease Risks You Can Change, and Those You Can't

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What Is Atrial Fibrillation?

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How to Quit Smoking

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Best Treatments for a Heart Attack

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What You Must Do if You Think You Are Having a Heart Attack

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Friday, December 7, 2012

Stomach-Acid-Suppressing Drugs May Raise Risk of Death After Angioplasty

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stomach-acid-drug TUESDAY, Nov. 17, 2009 (Health.com) — Heart patients who take certain stomach-acid-suppressing drugs to prevent gastrointestinal bleeding may be at increased risk of dying after a cardiac procedure, according to a study presented at the annual meeting of the American Heart Association (AHA) in Orlando.

Researchers at Mount Sinai Medical Center, in New York City, reported that patients who underwent angioplasty, a procedure to clear blocked blood vessels in the heart, were 30% more likely to die if they were taking proton pump inhibitors (PPIs).

It’s unclear whether the patients in the study who were prescribed these medications were sicker than those who weren’t, and thus more likely to die. The study's lead author, Joseph M. Sweeny, MD, a cardiologist at Mount Sinai, says that he will continue to follow current guidelines on prescribing PPIs, but that he will also be "very careful" in deciding which of his patients need to be on the drugs.

Before undergoing angioplasty, heart patients are typically prescribed blood-thinning drugs such as aspirin and Plavix, which increase the risk of stomach bleeding and ulcers. In a joint statement issued in 2008, the AHA, the American College of Gastroenterology, and the American College of Cardiologists indicated that PPIs could help prevent stomach bleeding in people at high risk.

But some experts have raised concerns that PPIs could make Plavix less effective because they block the action of enzymes that are crucial for metabolizing the blood-thinning drug. A number of studies have suggested that mixing the two drugs could be risky for patients, while others have not.

The study examined some 8,300 angioplasty patients who had had drug-secreting stents placed in their hearts to prop open narrowed blood vessels. In all, 17% of the patients were prescribed PPIs.

During the follow-up period, which lasted an average of two years, 602 patients died. When Dr. Sweeny and his colleagues broke patients into groups according to which PPI they were taking, they found that omeprazole (Prilosec) and pantoprazole (Protonix) were associated with an increased risk of death of 72% and 54%, respectively, in the years following the procedure.

Two other PPIs, esomeprazole (Nexium) and lansoprazole (Prevacid), were not associated with a greater risk of dying after the procedure. It’s not clear whether this means some PPIs were safer than others, says Dr. Sweeny.

“The numbers that I got were very dramatic,” Dr. Sweeny says. “You have to raise questions as to exactly what this is coming from.”

The findings need to be interpreted cautiously, he adds, because the patients who were taking PPIs may have been sicker to begin with. “What the clinical implications of this are right now I don’t know,” he says. However, the risk of death and complications after angioplasty is relatively low overall.

“The jury is still out regarding acid-suppressing medications and Plavix,” says Shoshana J. Herzig, MD, a researcher at Beth Israel Deaconess Medical Center and Harvard Medical School, in Boston, who didn’t participate in Dr. Sweeny’s study.

Because overall mortality in the current study was greater among the patients on PPIs, says Dr. Herzig, it’s definitely possible they may have been sicker in the first place.

Even so, she says, “I think that it’s fairly clear that in patients who are on Plavix and an acid-suppressing medication, we should evaluate whether they actually need that acid-suppressing medication.” Although PPIs usually aren’t intended to be taken indefinitely, patients often wind up staying on the drugs anyhow, she says.

At least in ICU patients, Dr. Herzig says, PPIs are prescribed too often, in large part because the ulcer drugs are viewed as very safe. However, she adds, rarer side effects do come to light when a drug is prescribed to millions of people.

Any patient who is prescribed a PPI, Dr. Herzig and Dr. Sweeny agree, should ask their physician why, and find out how long they need to take the medication.

At the American Heart Association's annual Scientific Sessions meeting, more than 20,000 cardiologists and other physicians from around the country give presentations on new research and on advances in the diagnosis and treatment of heart disease and stroke.

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