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House continues the decline started last episode.
Lue, an eight year old Hmong boy dreams of being choked and wakes up unable to breathe. He is taken to the ER in acute respiratory distress (but apparently gets better) and ends up admitted to House’s service for evaluation. House tells the team that SUNDS (sudden nocturnal unexpected death syndrome) is more commonly seen in Hmong immigrants, but cautions the team that SUNDS is the easy way out — he wants a real diagnosis. Initial thoughts include ventricular fibrillation due to catecholamine (chemicals like adrenalin) release from a nightmare, obstructive sleep apnea, lung damage from inhaled toxins, or an upper respiratory infection (URI). House starts Lue on antibiotics for pneumonia and has the team search his house for toxins. The search turns up no toxins, but they do find a ritually slaughtered pig in Lue’s bedroom – a Hmong exorcism rite carried out by his grandfather who believes that Lue is possessed by a demon.
About this time, Lue slips into ventricular tachycardia (v-tach, a potentially fatal arrhythmia), but is brought back to a normal heart rhythm by defibrillation and medication. Bearing in mind the new cardiac symptoms — plus the team has learned Lue’s father is in prison for murder — the differential diagnosis now includes PTSD (post traumatic stress disorder), a malignant arrhythmia (a term for a potentially fatal arrhythmia), or acute pericarditis (inflammation of the membranous sac surrounding the heart). House favors the latter and has the team check an echocardiogram, which is normal. Lue starts to complain of abdominal pain, so the team quickly ultrasounds his belly and finds no evidence of obstruction, but does find constipation. Chase now suspects Hashimoto’s thyroiditis so wants a thyroid biopsy. Lue refuses and shouts in Hmong, a language he doesn’t know, before suffering a seizure. These neurological symptoms have the team again changing their differential diagnosis, which now contains scleroderma and Rasmussen’s encephalitis (an inflammatory disease of the brain in children). An MRI is checked, but is normal. Lue again suffers a bad dream of someone choking him, but this time he awakens with bruises on his neck. The team now considers the diagnoses of a coagulopathy (easy bleeding because of problems clotting blood), anemia, vitamin C deficiency, or leukemia. House suggests liver failure, which the team takes to mean hepatic fibrosis. A liver biopsy is checked, but is negative.
Adams and Taub walk in to check on Lue, and find him levitating in bed, briefly, his grandfather beside him. They insist to House and the rest of the team that the levitation was real, but the others suggests muscle spasm, tetanus, or hypocalcemia (low blood calcium) as possibilities. House favors the hypocalcemia suggestion and wants the team to “pump up” Lue’s electrolytes and start him on a beta-blocker. Meanwhile, Lue’s mother is coming around to his grandfather’s way of thinking. She wants to perform another Hmong exorcism. Foreman convinces her to wait twenty-four hours, but when Lue becomes unresponsive, she and the grandfather proceed with the ceremony. While the ceremony proceeds in Lue’s room, the team goes through other possible diagnoses. Brugada and Long QT syndrome (inherited heart rhythm disorder) tests are all negative. Carotid aneurysms are suggested, but dismissed. Kawasaki’s disease is suggested and Adams immediately wants to proceed with cardiopulmonary bypass. House mentions that he thinks Lue has a PDA (patent ductus arteriosis). The ductus is a bypass in the heart important for the fetal circulation, but it should close shortly after birth.) that was infected and is causing the symptoms. After a heated discussion with the team, he allows them only to treat their suspicion – Kawasaki’s – but after Lue starts crashing, Adams slips him ibuprofen, the treatment for PDA. Lue recovers, but his mother and grandfather credit the religious ceremony, not any medical treatment.
This week demonstrated some of the most inept and nonsensical medicine I have seen yet on House. For pretty much every diagnosis, just ask: “Do the symptoms fit, at all?” The likely answer is NO. Rather than waste your bandwidth and mine by repeating that over and over, I’ll just hit the highlights (lowlights). As always, major complaints are in red (red caduceus), modest complaints are in blue (blue Vicodin), and nit-picking ones in green (green pencils):
A previously normal eight-year child suddenly begins to have PDA symptoms. His mother never noticed difficulty breathing before – it just started now, eight years after developing the PDA? Maybe that was the mysterious “PSA infection” House was referring to which was supposedly treated by the antibiotics – yet the patient’s symptoms worsened after the antibiotics.
A PDA severe enough to cause symptoms at rest and no murmurs on exam, or abnormal echocardiogram? (admittedly, a standard echocardiogram is not the best way to diagnose a PDA, but there should have been signs in one that severe, particularly one that’s “infected”).I’ll agree that a PDA can cause some shortness of breath or respiratory distress, but that’s different than a sensation of being choked. Furthermore, how does the PDA explain the seizure, speaking in tongues, or bruising.As a side note, another repeat final diagnosis. Seen previously in episode #513, “Big Baby“
Right after Adams suggests URI, House has her start IV antibiotics for pneumonia – which is a lower respiratory disease.
Exactly what evidence for Kawaski’s is there? Where was the fever, rash, conjunctivitis, induration of the skin on the extremities, mucosal erythema, and cervical lymphadenopathy?
See if you can spot the theme:How about some actual evidence for liver failure before poking a hole in the liver.How about some actual evidence for Hashimotos before poking a hole in the thyroid.How about some actual evidence for Kawasaki’s before poking a hole in the heart. (Stopped before they got this far, but they did suggest it and start the paperwork)
How about checking for low calcium before treating it?
I can find no evidence that beta-blockers are indicated for hypocalcemia.
The medical mystery was interesting, and maintained interest throughout the episode. I give it an A-. The final solution wasn’t great. The final diagnosis didn’t fit well at all from both a time course and a symptom point of view, plus — for the second week in a row — it was a retread. I give it a D-. I realize they were playing a faith versus medicine angle this week, which is a shame, because the medicine was horrible. The team leapt from diagnosis to diagnosis, without logic, and abandoning previous attempts at the drop of a hat. It earns a weak D-. They rushed to risky procedures with no good reasons or proof. The soap opera was fair. The House and Dominika scenes were good, but the House-tells-the-team-what-they’re-secretly-thinking has been overplayed this season. I give it a C+.
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