Sleep-dependent memory consolidation in patients with sleep disorders

Sleep can improve the off-line memory consolidation of new items of declarative and non-declarative information in healthy subjects, whereas acute sleep loss, as well as sleep restriction and fragmentation, impair consolidation. This suggests that, by modifying the amount and/or architecture of sleep, chronic sleep disorders may also lead to a lower gain in off-line consolidation, which in turn may be responsible for the varying levels of impaired performance at memory tasks usually observed in sleep-disordered patients.

The experimental studies conducted to date have shown specific impairments of sleep-dependent consolidation overall for verbal and visual declarative information in patients with primary insomnia, for verbal declarative information in patients with obstructive sleep apnoeas, and for visual procedural skills in patients with narcolepsy-cataplexy.

These findings corroborate the hypothesis that impaired consolidation is a consequence of the chronically altered organization of sleep. Moreover, they raise several novel questions as to: a) the reversibility of consolidation impairment in the case of effective treatment, b) the possible negative influence of altered prior sleep also on the encoding of new information, and c) the relationships between altered sleep and memory impairment in patients with other (medical, psychiatric or neurological) diseases associated with quantitative and/or qualitative changes of sleep architecture.

Table 1. Methodological characteristics and results of the experimental studies on memory consolidation during sleep in patients with chronic sleep disorders.

Abbreviations: DM = declarative memory; NC = narcolepsy with cataplexy; NDM = non declarative memory; OSA = obstructive sleep apnoea; PI = primary insomnia; REM = rapid eye movement (sleep); REMD = REM density; SE = sleep efficiency; SWS = slow wave sleep; SPT = sleep period time; SFI = sleep fragmentation index; SOA= stimulus onset asynchrony; TST = total sleep time; WASO = wake after sleep onset.

View Within Article

Copyright © 2012 Elsevier Ltd. All rights reserved.

View the original article here