Senior syndrome – ken is a rare condition characterized by the combination of two specific functions: a kidney condition called nephronophthisis and ocular disease known as congenital Leber amaurosis.
Nephronophthisis causes fluid-filled cysts develop in the kidneys begin during childhood. These cysts affect kidney function, initially causing increased urine production (polyuria) and excessive thirst (polydipsia), general weakness and extreme tiredness (fatigue). Nephronophthisis leading to end-terminal chronic renal failure (ESRD) later in childhood or adolescence. ESRD is a life-threatening renal function insufficiency occurs when the kidneys are no longer able to filter efficiently liquids and waste products from the body.
Amaurosis congenita of Leber mainly affects the retina, that is the specialized tissue in the back of the eye that senses light and color. This condition causes vision problems, including an increased sensitivity to light (photophobia), involuntary eye movements (nystagmus) and extreme farsightedness (hyperopia). Some people with the syndrome of Senior-L ken develop signs of congenital Leber amaurosis within the first few years of life, while others do not develop vision problems until later in childhood.
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The following resources on Senior syndrome-L ken may be useful. These materials are written for the general public.
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