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Monday, July 2, 2012

NLM Announces public release of papers of John b. Calhoun, NIH researcher noted social crowding and aggression

The history of Medicine Division, national library of Medicine (NLM) announces the public release of documents from John b. Calhoun (1917-1995), a researcher of behavioral sciences noted at the National Institute of Mental Health (NIMH), a component of the National Institutes of Health. From the 1950s through the 1980s, Dr. Calhoun has studied the behavior of mice and rats in conditions of extreme overcrowding. He, along with other social scientists, politicians and pundits, readily extrapolated his work to comment on Human crowding in urban environments, just as the country was undergoing a massive redevelopment of its urban structures. His conclusions have found a ready audience among those who saw the world's overpopulation as not only a problem of resources, but of social cohesion.

In a statement, Calhoun's work with rats inspired 1971 children's book, Mrs. Frisby and the rats of NIMH by Robert c. O'Brien, which was adapted into an animated film of 1982, the secret of NIMH.

John b. Calhoun was born in Elkton, Tennessee, in 1917. After his undergraduate education at the University of Virginia (B.A., 1939) and postgraduate work in zoology from Northwestern University (PhD, 1943), post-graduate work and Professor at Emory University, Ohio State University and the Johns Hopkins University School of hygiene and public health, studying sociology and ecology of Norway rats. After further work at the Jackson Memorial Laboratory, Bar Harbor, Maine and the army Graduate School at Walter Reed Army Medical Center, in 1954 he joined the section on perception in psychology laboratory at NIMH. He spent the rest of his career.

Study rats in conditions of overcrowding, Calhoun observed what he termed the "behavioural sink". This aberrant behavior as indicated hyperaggression, inability to reproduce normally, infant cannibalism, increased mortality and aberrant sexual models in such situations of overcrowding. His general conclusion was that "the space itself is a necessity". In the 1960s, his research switched in the field of evolution and behavior, which informs the current field of evolutionary psychology. In 1963 he formed and was the first Director of the NIMH for behavioral systems research (URBS) in the laboratory of brain evolution and behavior (LBEB). There he observed the effects of crowding on a community of mice that have been permitted to overpopulate, seeing a complete end to play, with the entire population died. Calhoun coined the term "Autism" to describe the behavior of the Group at that point finale, how I became incapable of social interaction is essential for survival. In the mid-1970s, his research moved to turn to cultural ways that rats acquired to counteract the effects of overcrowding.

Calhoun retired from NIMH in 1984, but continued to work on his research results until his death on September 7, 1995.

The collection, "MS C 586," comprises 196 linear metres of records mostly material from 1954 to 1986. It was donated in 1997, as a gift from Edith Calhoun, his widow. In addition to laboratory notebooks and drafts of articles, the collection is particularly noteworthy for the film, video cassettes and spools audiocassettes that Dr. Calhoun used to document his experiments.

Calhoun cards form one of the collections of research described almost 600 of modern manuscripts of the library program. I am one of a vast number of human development and behavioral sciences; others include the papers of Bertram Brown, Wayne Dennis, Lawrence k. Frank, Paul MacLean, Lois Meek, Lois b. Murphy and Herbert Rowell Stolz, as well as the records of the Society for Research in Child Development and Child Guidance Clinic and child psychiatry movement interview collection.

Calhoun materials can be found in the history of Medicine Division reading room, National Library of Medicine, open Monday to Friday, from 17: 8:30 to 0, except for Federal holidays on the first floor of the building on 38 NIH campus, Bethesda, Maryland. No appointment is necessary. Finding aid for the collection can be found at http://oculus.nlm.nih.gov/cgi/f/findaid/findaid-idx?c=nlmfindaid;idno=calhoun586.

The National Library of Medicine, the largest medical library in the world, is a component of the National Institutes of Health.

Dr. John B. Calhoun points to two tail-wounded mice on his arm from universe 17, study 102. November, 1969.

Dr. John b. Calhoun points to two injured mice tail on her arm from Universe 17, 102. November 1969.

A view of mouse universe 33, showing four cells of group 01 during week 162 of an experiment, possibly study 133. C.1975.

A view of the universe mouse 33, showing four group cells 01 week 162 of an experiment, study possibly 133. C. 1975.


View the original article here

NLM Announces public release of papers of John b. Calhoun, NIH researcher noted social crowding and aggression

The history of Medicine Division, national library of Medicine (NLM) announces the public release of documents from John b. Calhoun (1917-1995), a researcher of behavioral sciences noted at the National Institute of Mental Health (NIMH), a component of the National Institutes of Health. From the 1950s through the 1980s, Dr. Calhoun has studied the behavior of mice and rats in conditions of extreme overcrowding. He, along with other social scientists, politicians and pundits, readily extrapolated his work to comment on Human crowding in urban environments, just as the country was undergoing a massive redevelopment of its urban structures. His conclusions have found a ready audience among those who saw the world's overpopulation as not only a problem of resources, but of social cohesion.

In a statement, Calhoun's work with rats inspired 1971 children's book, Mrs. Frisby and the rats of NIMH by Robert c. O'Brien, which was adapted into an animated film of 1982, the secret of NIMH.

John b. Calhoun was born in Elkton, Tennessee, in 1917. After his undergraduate education at the University of Virginia (B.A., 1939) and postgraduate work in zoology from Northwestern University (PhD, 1943), post-graduate work and Professor at Emory University, Ohio State University and the Johns Hopkins University School of hygiene and public health, studying sociology and ecology of Norway rats. After further work at the Jackson Memorial Laboratory, Bar Harbor, Maine and the army Graduate School at Walter Reed Army Medical Center, in 1954 he joined the section on perception in psychology laboratory at NIMH. He spent the rest of his career.

Study rats in conditions of overcrowding, Calhoun observed what he termed the "behavioural sink". This aberrant behavior as indicated hyperaggression, inability to reproduce normally, infant cannibalism, increased mortality and aberrant sexual models in such situations of overcrowding. His general conclusion was that "the space itself is a necessity". In the 1960s, his research switched in the field of evolution and behavior, which informs the current field of evolutionary psychology. In 1963 he formed and was the first Director of the NIMH for behavioral systems research (URBS) in the laboratory of brain evolution and behavior (LBEB). There he observed the effects of crowding on a community of mice that have been permitted to overpopulate, seeing a complete end to play, with the entire population died. Calhoun coined the term "Autism" to describe the behavior of the Group at that point finale, how I became incapable of social interaction is essential for survival. In the mid-1970s, his research moved to turn to cultural ways that rats acquired to counteract the effects of overcrowding.

Calhoun retired from NIMH in 1984, but continued to work on his research results until his death on September 7, 1995.

The collection, "MS C 586," comprises 196 linear metres of records mostly material from 1954 to 1986. It was donated in 1997, as a gift from Edith Calhoun, his widow. In addition to laboratory notebooks and drafts of articles, the collection is particularly noteworthy for the film, video cassettes and spools audiocassettes that Dr. Calhoun used to document his experiments.

Calhoun cards form one of the collections of research described almost 600 of modern manuscripts of the library program. I am one of a vast number of human development and behavioral sciences; others include the papers of Bertram Brown, Wayne Dennis, Lawrence k. Frank, Paul MacLean, Lois Meek, Lois b. Murphy and Herbert Rowell Stolz, as well as the records of the Society for Research in Child Development and Child Guidance Clinic and child psychiatry movement interview collection.

Calhoun materials can be found in the history of Medicine Division reading room, National Library of Medicine, open Monday to Friday, from 17: 8:30 to 0, except for Federal holidays on the first floor of the building on 38 NIH campus, Bethesda, Maryland. No appointment is necessary. Finding aid for the collection can be found at http://oculus.nlm.nih.gov/cgi/f/findaid/findaid-idx?c=nlmfindaid;idno=calhoun586.

The National Library of Medicine, the largest medical library in the world, is a component of the National Institutes of Health.

Dr. John B. Calhoun points to two tail-wounded mice on his arm from universe 17, study 102. November, 1969.

Dr. John b. Calhoun points to two injured mice tail on her arm from Universe 17, 102. November 1969.

A view of mouse universe 33, showing four cells of group 01 during week 162 of an experiment, possibly study 133. C.1975.

A view of the universe mouse 33, showing four group cells 01 week 162 of an experiment, study possibly 133. C. 1975.


View the original article here

Keep Your Guard Up

AppId is over the quota
AppId is over the quota

April 6, 2012 / Vol. 61 / No. RR–2
Good Laboratory Practices for Biochemical Genetic Testing and Newborn Screening for Inherited Metabolic Disorders
CE Available

This report provides recommendations for good laboratory practices for biochemical genetic testing and newborn screening for inherited metabolic disorders. The recommended practices address the benefits of using a quality management system approach, factors to consider before introducing new tests, establishment and verification of test performance specifications, the total laboratory testing process, confidentiality of patient information and test results, and personnel qualifications and responsibilities for laboratory testing for inherited metabolic diseases. These recommendations are intended for laboratories that perform biochemical genetic testing to improve the quality of laboratory services and for newborn screening laboratories to ensure the quality of laboratory practices for inherited metabolic disorders. These recommendations also are intended as a resource for medical and public health professionals who evaluate laboratory practices, for users of laboratory services to facilitate their collaboration with newborn screening systems and use of biochemical genetic tests, and for standard-setting organizations and professional societies in developing future laboratory quality standards and practice recommendations.


View the original article here

New topic on Genetics Home Reference: Senior-Løken syndrome

Senior syndrome – ken is a rare condition characterized by the combination of two specific functions: a kidney condition called nephronophthisis and ocular disease known as congenital Leber amaurosis.

Nephronophthisis causes fluid-filled cysts develop in the kidneys begin during childhood. These cysts affect kidney function, initially causing increased urine production (polyuria) and excessive thirst (polydipsia), general weakness and extreme tiredness (fatigue). Nephronophthisis leading to end-terminal chronic renal failure (ESRD) later in childhood or adolescence. ESRD is a life-threatening renal function insufficiency occurs when the kidneys are no longer able to filter efficiently liquids and waste products from the body.

Amaurosis congenita of Leber mainly affects the retina, that is the specialized tissue in the back of the eye that senses light and color. This condition causes vision problems, including an increased sensitivity to light (photophobia), involuntary eye movements (nystagmus) and extreme farsightedness (hyperopia). Some people with the syndrome of Senior-L ken develop signs of congenital Leber amaurosis within the first few years of life, while others do not develop vision problems until later in childhood.

These resources address the diagnosis or management of Senior-L ken and may include providers of treatment.

You may also find information about the diagnosis or management of Senior-L ken in patient support and educational resources.

To locate a healthcare provider, see how do I find a genetics professional in my area? in the manual.

The following resources on Senior syndrome-L ken may be useful. These materials are written for the general public.

You may also be interested in these resources, which are designed for health professionals and researchers.

This manual provides basic information on genetics in clear language.

These links provide additional resources that may be useful to genetics.

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a genetic disease, syndrome or condition should consult with a qualified healthcare provider. See how do I find a genetics professional in my area? in the manual.


View the original article here

New topic on Genetics Home Reference: Senior-Løken syndrome

Senior syndrome – ken is a rare condition characterized by the combination of two specific functions: a kidney condition called nephronophthisis and ocular disease known as congenital Leber amaurosis.

Nephronophthisis causes fluid-filled cysts develop in the kidneys begin during childhood. These cysts affect kidney function, initially causing increased urine production (polyuria) and excessive thirst (polydipsia), general weakness and extreme tiredness (fatigue). Nephronophthisis leading to end-terminal chronic renal failure (ESRD) later in childhood or adolescence. ESRD is a life-threatening renal function insufficiency occurs when the kidneys are no longer able to filter efficiently liquids and waste products from the body.

Amaurosis congenita of Leber mainly affects the retina, that is the specialized tissue in the back of the eye that senses light and color. This condition causes vision problems, including an increased sensitivity to light (photophobia), involuntary eye movements (nystagmus) and extreme farsightedness (hyperopia). Some people with the syndrome of Senior-L ken develop signs of congenital Leber amaurosis within the first few years of life, while others do not develop vision problems until later in childhood.

These resources address the diagnosis or management of Senior-L ken and may include providers of treatment.

You may also find information about the diagnosis or management of Senior-L ken in patient support and educational resources.

To locate a healthcare provider, see how do I find a genetics professional in my area? in the manual.

The following resources on Senior syndrome-L ken may be useful. These materials are written for the general public.

You may also be interested in these resources, which are designed for health professionals and researchers.

This manual provides basic information on genetics in clear language.

These links provide additional resources that may be useful to genetics.

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a genetic disease, syndrome or condition should consult with a qualified healthcare provider. See how do I find a genetics professional in my area? in the manual.


View the original article here

Catch Cancer Early

AppId is over the quota
AppId is over the quota

April 6, 2012 / Vol. 61 / No. RR–2
Good Laboratory Practices for Biochemical Genetic Testing and Newborn Screening for Inherited Metabolic Disorders
CE Available

This report provides recommendations for good laboratory practices for biochemical genetic testing and newborn screening for inherited metabolic disorders. The recommended practices address the benefits of using a quality management system approach, factors to consider before introducing new tests, establishment and verification of test performance specifications, the total laboratory testing process, confidentiality of patient information and test results, and personnel qualifications and responsibilities for laboratory testing for inherited metabolic diseases. These recommendations are intended for laboratories that perform biochemical genetic testing to improve the quality of laboratory services and for newborn screening laboratories to ensure the quality of laboratory practices for inherited metabolic disorders. These recommendations also are intended as a resource for medical and public health professionals who evaluate laboratory practices, for users of laboratory services to facilitate their collaboration with newborn screening systems and use of biochemical genetic tests, and for standard-setting organizations and professional societies in developing future laboratory quality standards and practice recommendations.


View the original article here

Tuesday, June 26, 2012

New Eyewear For the Whole family from Crocs

crocssunglasses New Eyewear For the Whole family from CrocsThe Grundig family lives in Crocs in the summer, and since school got out officially today, I’m considering it summer.  I was so happy to hear that our favorite summer shoe brand has just come out with a new eyewear collection for the whole family.

As a mom with a young boy and girl, I have a hard time keeping their eyes safe.  While they’ll happily wear bug repellent and sunscreen, they aren’t too excited about wearing sunglasses.  So I need sunglasses that are not only high-quality, but are also lightweight and easy to wear.  The new Crocs eyewear line is perfect.  The glasses are stylish and fun, with interchangeable hinges for some style changes.  But, they are also a nice size – covering the whole eye.  And, they are lightweight so they aren’t too heavy for my kids to wear.

To learn more about the new Crocs eyewear line, visit their website.

Disclosure: I received samples at no cost for review.

pixel New Eyewear For the Whole family from Crocs Tagged as: crocs, sunglasses


View the original article here

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