What (Not) to Wear in Europe: Men's Edition

AppId is over the quota
AppId is over the quota

By Rachel Felder

Gearing up for a summer getaway is certainly exciting; figuring out what's appropriate to wear on your trip, well, not so much. Whether you're heading to a vibrant European capital or an ultra-relaxing beach resort, knowing what to pack can be a daunting task. For men, the safest plan, regardless of destination, is to keep things simple, packing versatile basics in neutral shades of navy, gray, khaki, black, and white.

"I would definitely bring an unlined blazer that's comfortable and more casual but still gives you the look of a tailored jacket," suggests Matt Marden, Fashion Market Director at DETAILS magazine. "Something like a navy suit or a gray suit is also great to bring because you can break up the pieces and dress them up or down with a white button down or a navy blue t-shirt."

Marden also suggests bringing jeans in dark denim (since it's more polished than lighter washes), a pair of comfortable dress shoes, and a pair of classic white sneakers, which can be worn with a suit (to give it a more casual feel) as well as shorts and a simple tee.

Of course, some of what needs to be packed depends on where you're going. Here are Marden's tips for the most popular types of summer destinations:

"If you're going to be in a city in the summer, it's great to get key items in fabrics like cotton and linen," Marden advises. "They have an effortless feel to them and look chic even if they get wrinkly." What not to pack? "I would not bring anything like a flip-flop, any sort of gym shorts unless you're going to run in them, or graphic t-shirts or destination t-shirts. Most quote unquote 'tacky tourists' wear a lot of logos, so I would avoid logos at all costs, even on your luggage."

For this type of trip, the goal is to look relaxed and lowkey "I love wearing a pair of shorts—more of a tailored short, nothing 'cargoey' with tons of pockets—with a dress shoe if you're going to a small town," Marden says "Another great thing is bringing a grey sweatshirt, because that looks good with khakis and it's super comfortable, easy, and breathable if you're running all around. If you're sightseeing in the morning and it's cool you can wear it, then wrap it around your waist or shoulders as it gets warmer later in the day."

"Unless you're a male model or an Olympian—or have the body of either—you don't want to be rocking a Speedo on the beach," Marden laughs, suggesting that swim trunks should fall between mid-thigh and just above the knee. "Grown men should not be wearing any sort of board shorts because that gets to be a little goofy."

For the journey to and from your destination, Marden says the priority is ease. "I love a chino on the airplane, or a dress pant, because they're comfortable," he says. "Jeans get to be too heavy sometimes. A slim fitting cargo pant also would work." He also suggests wearing a cardigan sweater, since planes can get drafty.

For up-to-the-minute hotel and restaurant recommendations, as well as the best planning advice, check out our Europe Travel Guide.

But although it's important to be comfortable, particularly for long haul flights, Marden says not to take that goal too far. "I would never wear sweatpants," he says.

Photo Credits: Chic European City: TommL/iStockphoto.com; Small Town:

View the original article here

Read More

Disease Tolerance as a Defense Strategy

AppId is over the quota AppId is over the quota

Abstract
The immune system protects from infections primarily by detecting and eliminating the invading pathogens; however, the host organism can also protect itself from infectious diseases by reducing the negative impact of infections on host fitness. This ability to tolerate a pathogen’s presence is a distinct host defense strategy, which has been largely overlooked in animal and human studies. Introduction of the notion of “disease tolerance” into the conceptual tool kit of immunology will expand our understanding of infectious diseases and host pathogen interactions. Analysis of disease tolerance mechanisms should provide new approaches for the treatment of infections and other diseases.

Posted in Autoimmune disease, evolutionary medicine

 

Read More

Disease Tolerance as a Defense Strategy

AppId is over the quota AppId is over the quota

Abstract
The immune system protects from infections primarily by detecting and eliminating the invading pathogens; however, the host organism can also protect itself from infectious diseases by reducing the negative impact of infections on host fitness. This ability to tolerate a pathogen’s presence is a distinct host defense strategy, which has been largely overlooked in animal and human studies. Introduction of the notion of “disease tolerance” into the conceptual tool kit of immunology will expand our understanding of infectious diseases and host pathogen interactions. Analysis of disease tolerance mechanisms should provide new approaches for the treatment of infections and other diseases.

Posted in Autoimmune disease, evolutionary medicine

 

Read More

Disease Tolerance as a Defense Strategy

AppId is over the quota AppId is over the quota

Abstract
The immune system protects from infections primarily by detecting and eliminating the invading pathogens; however, the host organism can also protect itself from infectious diseases by reducing the negative impact of infections on host fitness. This ability to tolerate a pathogen’s presence is a distinct host defense strategy, which has been largely overlooked in animal and human studies. Introduction of the notion of “disease tolerance” into the conceptual tool kit of immunology will expand our understanding of infectious diseases and host pathogen interactions. Analysis of disease tolerance mechanisms should provide new approaches for the treatment of infections and other diseases.

Posted in Autoimmune disease, evolutionary medicine

 

Read More

What to Do This Summer in Paris, NYC, Rome, Las Vegas, London, and DC

AppId is over the quota
AppId is over the quota

By Adam Erace

It is that time of year, when the sun (and birds and trees and relaxed smiles from otherwise serious city dwellers) comes out in full force, inviting us out of our cloistered apartments and into the world. There are some places that draw us in over and over again for both their storied sights and endlessly cool vibes. So we took stock of six of the most popular summertime destinations—Paris, NYC, Rome, Las Vegas, London, and Washington DC—to see what's new for this year. And, as expected, we found ample new restaurants and buzz-worthy cafes, exciting exhibits and enticing festivals, and a string of new hotels offering everything a summer traveler could want.

Why Go Now: Even the most severely stylish Parisian lets her hair down in the summer. Find locals grooving at la Fete de la Musique (June 21), when thousands of musicians turn the city into a giant concert hall; sunbathing at the Seine-side pop-up pools and beaches of the Paris Plages project (July 20-Aug. 20); and attending free screenings of at the Parc de la Villette's Cinema en Plein Air (July 25-Aug. 26). The film schedule isn't set yet, but if 2011's lineup is any indication, expect anything from Taxi Driver to La Haine.

Where to Stay: Like a dainty pastel macaron, Paris hotels are never big enough. Avoid cramped quarters by taking shelter at My Boutique Home (rates from $899/week) on the fringe of the aristocratic Marais. Fully renovated last year, the two apartments—book them together to really stretch those weary legs—have floating fireplaces, wrought-iron spiral stairs, and gourmet kitchens to make the most of the nearby Marché des Enfants Rouges.

Where to Eat: Anglofied steakhouse fare (dry-aged chops, bespoke burgers) is Paris's hot ticket at the moody, subway-tiled Beef Club. Courtesy of the crew behind Experimental Cocktail Club, Curio Parlor, and Prescription, this two-month-old former butcher shop also houses an underground speakeasy, Le Ballroom du Beef Club, where locals sip summery, bitters-kissed coolers late into the evening.

Start Planning: For up-to-the-minute hotel, restaurant, and shopping reviews, as well as the best planning advice, check out our Paris Travel Guide.

Why Go Now: Manhattan's elite have absconded to their summer manses, leaving young New Yorkers to retake the city. While it might not boast an ocean, there's a bevy of outdoor pursuits in swing, the coolest of which take place on Governor's Island, according to The London Hotel's concierge Nick Cejas. Think jazz-age lawn party (June 16-17), burger cook-off and kimchi-eating contest (July 6-7) and the third annual Pig Island (Sept. 10), a food extravaganza celebrating local pork and craft beer.

Where to Stay: The London Hotel (rates from $299/night) is where you'll not only find Cejas, but also many a passing-through celeb. Sophisticated suites (Italian linens, Waterworks bathrooms) start at 500-square feet, nothing to wag a finger at in New York.

Where to Eat: Back outside on the Williamsburg waterfront, Smorgasburg (an edible offshoot of Brooklyn Flea) is the delectable Mecca of what New York magazine recently dubbed "Ye Olde Artisanal Brooklyn." Over 60 food entrepreneurs gather here every Saturday to sell everything from kimchi-topped franks at Asia Dog and cardamom marshmallows at Whimsy & Spice to gingered horseradish at ISH and fried anchovies at Bon Chovie. It's particularly pleasant in early summer, when the weather isn't yet warm enough to melt the mayo in your Red Hook Lobster Pound lobster roll. (Bonus tip: the year-old East River Ferry stops just feet from the entrance to Smorgasburg at the North Williamsburg stop.)

Start Planning: For up-to-the-minute hotel, restaurant, and shopping reviews, as well as the best planning advice, check out our New York City Travel Guide.

Why Go Now: This is the summer of anniversaries: Charles Dickens's 200th, Titanic's 100th, Queen Elizabeth's 60th on the throne, marked by a Diamond Jubilee celebration (June 6) with floating pageant on the Thames. The royal event aligns with new unparalleled access to Kensington Palace (fresh exhibits on Diana and Victoria) and the Crown Jewels at the Tower of London. There's also this little thing you may have heard of called the Summer Olympics (July 27-Aug. 12).

Where to Stay: ME, Melia's sexy younger sister, opens its 173-room Covent Garden property on July 15th (rates from $399). Cool gray-on-white suites on the coveted Level feature balconies with Thames views, integrated media centers, and dedicated Aura Experience Managers, otherwise known as butlers.

Where to Eat: Wide-plank floors, lazy ceiling fans and turquoise accents give Soho's new Ceviche the aura of well-groomed Peruvian fishing shack. Six styles of marinated fish make use of salmon, octopus, sea bass, South American chilies, and assorted citrus juices, ideal for cooling down when London heats up.

Start Planning: For up-to-the-minute hotel, restaurant, and shopping reviews, as well as the best planning advice, check out our London Travel Guide.

Why Go Now: You've heard it before, but it's never been truer than this summer: There's so much more to do in Vegas than gamble. The World Series of Poker comes to the Rio (July 1), while Idina Menzel (June 10), Diana Krall (Aug. 13), Steve Martin (Aug. 22), and more come to the Smith Center for the Performing Arts. Museums (blessedly air conditioned) abound, specializing in everything from the mafia (Mob Museum) to vintage pinball machines (Pinball Hall of Fame). With its "boneyard" of salvaged signs from the Strip, the Neon Museum proves one man's trash is Vegas's treasure.

Where to Stay: With more than a dozen restaurants (including Jaleo by Jose Andres and Comme Ca by David Myers) three pools, and a nightclub from the Tao crew, the glittering Cosmopolitan (rates from $140/night) isn't short on amenities. But here's why we're booking there this summer: balconies. All the subtly luxurious condo-style Terrace rooms have them, a true rarity in Vegas. Reserve a Fountain View (rates from $230/night) for a drop-dead panorama of the Strip and Bellagio's dancing waters.

Where to Eat: Two words: Japanese food. Vegas has the highest caliber concentration of Japanese cuisine this side of Tokyo, both on the Strip (Masa Takayama's airy BARMASA at Aria, the Cosmopolitan's outpost of New York's Blue Ribbon) and off (Aburiya Raku, Kabuto).

Start Planning: For up-to-the-minute hotel, restaurant, and shopping reviews, as well as the best planning advice, check out our Las Vegas Travel Guide.

Why Go Now: There's no getting around it: Roman summers are muggy and crowded (except in August, when the Eternal City becomes a latter-day Roanoke Island), but on the bright side: Trastevere's secret Orto Botanico, a shady oasis with its own Japanese garden, is in bloom, and there's hardly a better time to paddelboat to Tempietto di Asclepio island in the Villa Borghese's stunning gardens. Rome Festival, which brings together international performance artists from all over the world, is really kicking this time of year, too; in June and July, catching a performance of Carmen or Falstaff is as common as licking a cone of gelato.

Where to Stay: After a long day sightseeing, repair to the chic Villa Magnolia Relais (rates from $240/night), a high-altitude retreat on the slope of Janiculum, Rome's second tallest hill. The airy suites boast soothing cream, caramel, gray, and olive tones, complimentary WiFi, and views of and direct access to the villa's exuberant garden. You'll feel a world away from the city's hot summer snarl, but the Vatican and the Coliseum are still only 20 minutes on foot, and at the bottom of the hill are the famed trattorias of Trastevere, of which Magnolia's proprietors, Sante and Rafaella Quaglieri, unwaveringly recommend Da Augusto (15 Piazza de Renzi).

Where to Eat: After carbonara coma kicks in, take a refresher at Monti's newish Aromaticus. Tucked inside an urban gardening oasis of the same name, the café serves cool and light carpaccio, organic salads, and beef tartare. Meanwhile at modern Metamorfosi in Parioli, chef Roy Caceres gives classics like maccheroni and sausage a playful, 21st-century spin. Try the 90 euro Assaporando option, a spontaneous, eight-course menu that Caceres and his crew invent on the spot.

Start Planning: For up-to-the-minute hotel, restaurant, and shopping reviews, as well as the best planning advice, check out our Rome Travel Guide.

Why Go Now: Tourism is climbing in the nation's capital, and there are few better times to see why than summer, when hotel rates drop and maddeningly popular restaurants exhale. Gastronomes, book passes to the Fancy Food Show (June 17-19), North America's largest. Gamers, "The Art of Video Games," a Smithsonian exhibit (through Sept.) examining the evolution of gaming from Atari to Playstation should be on your radar. Epic destruction is on the menu for 2012's NoMa Summer Screen, a free outdoor film series in Loree Grand Field; they'll be showing Independence Day, Ghostbusters, Jurassic Park, and more through Aug. 8.

Where to Stay: Staying a mere mile outside DC can translate to big savings for both wallet and carbon footprint. Just across the Potomac, the Renaissance Arlington Capital View (rates from $149/night) opened this spring with a LEED Gold certification, only the third hotel to do so in Virginia.

Where to Eat: Summer is your best chance for snagging a four-top—larger parties strictly prohibited—at the subterranean Little Serrow off Dupont Circle. Served on a $45 pre-fixe menu that changes weekly, chef Johnny Monis's razor-sharp interpretations of Thai recipes like naam phrik num will get you hot and bothered in the good way.

Start Planning: For up-to-the-minute hotel, restaurant, and shopping reviews, as well as the best planning advice, check out our Washington DC Travel Guide.

Photo Credits: Paris: via Shutterstock.com; Rome: Getty Images/iStockphoto; London: via Shutterstock.com; Vegas: Brandon Collup/iStockphoto.com; Washington D.C.: Medioimages/Photodisc; New York City: Pawel Gaul/iStockphoto.com

View the original article here

Read More

Emergence and evolution of the renin–angiotensin–aldosterone system

AppId is over the quota AppId is over the quota

The renin–angiotensin–aldosterone system (RAAS) is not the sole, but perhaps the most important volume regulator in vertebrates. To gain insights into the function and evolution of its components, we conducted a phylogenetic analysis of its main related genes. We found that important parts of the system began to appear with primitive chordates and tunicates and that all major components were present at the divergence of bony fish, with the exception of the Mas receptor. The Mas receptor first appears after the bony-fish/tetrapod divergence. This phase of evolutionary innovation happened about 400 million years ago. We found solid evidence that angiotensinogen made its appearance in cartilage fish. The presence of several RAAS genes in organisms that lack all the components shows that these genes have had other ancestral functions outside of their current role. Our analysis underscores the utility of sequence comparisons in the study of evolution. Such analyses may provide new hypotheses as to how and why in today’s population an increased activity of the RAAS frequently leads to faulty salt and volume regulation, hypertension, and cardiovascular diseases, opening up new and clinically important research areas for evolutionary medicine.

Posted in evolutionary medicine

 

Read More

Emergence and evolution of the renin–angiotensin–aldosterone system

AppId is over the quota AppId is over the quota

The renin–angiotensin–aldosterone system (RAAS) is not the sole, but perhaps the most important volume regulator in vertebrates. To gain insights into the function and evolution of its components, we conducted a phylogenetic analysis of its main related genes. We found that important parts of the system began to appear with primitive chordates and tunicates and that all major components were present at the divergence of bony fish, with the exception of the Mas receptor. The Mas receptor first appears after the bony-fish/tetrapod divergence. This phase of evolutionary innovation happened about 400 million years ago. We found solid evidence that angiotensinogen made its appearance in cartilage fish. The presence of several RAAS genes in organisms that lack all the components shows that these genes have had other ancestral functions outside of their current role. Our analysis underscores the utility of sequence comparisons in the study of evolution. Such analyses may provide new hypotheses as to how and why in today’s population an increased activity of the RAAS frequently leads to faulty salt and volume regulation, hypertension, and cardiovascular diseases, opening up new and clinically important research areas for evolutionary medicine.

Posted in evolutionary medicine

 

Read More

Emergence and evolution of the renin–angiotensin–aldosterone system

AppId is over the quota AppId is over the quota

The renin–angiotensin–aldosterone system (RAAS) is not the sole, but perhaps the most important volume regulator in vertebrates. To gain insights into the function and evolution of its components, we conducted a phylogenetic analysis of its main related genes. We found that important parts of the system began to appear with primitive chordates and tunicates and that all major components were present at the divergence of bony fish, with the exception of the Mas receptor. The Mas receptor first appears after the bony-fish/tetrapod divergence. This phase of evolutionary innovation happened about 400 million years ago. We found solid evidence that angiotensinogen made its appearance in cartilage fish. The presence of several RAAS genes in organisms that lack all the components shows that these genes have had other ancestral functions outside of their current role. Our analysis underscores the utility of sequence comparisons in the study of evolution. Such analyses may provide new hypotheses as to how and why in today’s population an increased activity of the RAAS frequently leads to faulty salt and volume regulation, hypertension, and cardiovascular diseases, opening up new and clinically important research areas for evolutionary medicine.

Posted in evolutionary medicine

 

Read More

Vigorous Exercise Might Protect Against Psoriasis

Click Here!
Women who engage in vigorous activities like running or aerobic exercise may have reduced risk of psoriasis


May 23, 2012 -- Here's yet another reason to exercise: A new study suggests that vigorous physical activity could reduce the risk of psoriasis.
The findings come out of the long-running Nurses' Health Study, which includes only women, but previous research suggests that exercise may also protect men against the chronic skin condition, characterized mostly by inflamed, scaly patches.
As many as 7.5 million Americans have psoriasis, according to the National Psoriasis Foundation, which says it's the most common autoimmune disease. Men and women are equally affected. Previous research has linked higher body mass index, or BMI, family history of psoriasis, alcohol use, and smoking to the risk of psoriasis.
In the new study, scientists followed nearly 87,000 female nurses for 14 years. None of them had been diagnosed with psoriasis at the beginning of the study. Over the course of the study, the nurses completed three detailed questionnaires about physical activity and were asked to report whether they were ever diagnosed with psoriasis. A total of 1,026 women said they were diagnosed during the study period and provided survey information about their physical activity.

Compared with no vigorous physical activity, vigorous exercise -- the equivalent of 105 minutes of running at a 6-mile-per-hour pace every week -- was associated with a 25% to 30% lower risk of psoriasis. The association remained significant after accounting for BMI, age, smoking, and alcohol use. The researchers say theirs is the first study to investigate the independent association between physical activity and psoriasis.
"The intensity of the exercise is the key," says researcher Abrar Qureshi, MD, MPH, vice chair of dermatology at Brigham and Women's Hospital and assistant professor at Harvard Medical School.
Only running and performing aerobic exercise or calisthenics were associated with a reduced risk of psoriasis. Other vigorous activities, such as jogging, playing tennis, swimming, and bicycling, were not. The researchers speculate that the highly variable intensity of the latter group of activities might account for the lack of an association with a lower psoriasis risk.
More than a decade ago, Siba Raychaudhuri, MD, reported that male and female psoriasis patients who exercised were likely to have less severe disease. "Walking was protective also," says Raychaudhuri, a rheumatologist at the University of California, Davis. He says he was "a little bit surprised" that Qureshi did not find that to be the case but added that "this study is more elegant than ours" because it collected more detailed information about exercise intensity.
Qureshi's team speculates that the lower risk of psoriasis in women who exercised vigorously might be due to a reduction in system-wide inflammation. Vigorous exercise also might be protective against psoriasis because it decreases anxiety and stress, which are tied to new cases and exacerbations of the disease, the researchers say.
"A good amount of data show that emotional stress reduction is good for psoriasis reduction," Raychaudhuri says.
Exposure to ultraviolet light is a psoriasis treatment, so time spent outdoors exercising, and not the exercise itself, might have explained the lowered risk of the disease, Qureshi says. But his study found that women who ran for only an hour a week had a significantly reduced risk of developing psoriasis than women who spent at least four hours walking outside at an average pace.
Chris Ritchlin, MD, MPH, a University of Rochester rheumatologist, calls Qureshi's findings "very interesting." Still, Ritchlin says, while exercise is known to be associated with reduced inflammation, "is there something about people who are really athletically inclined that we're not thinking about that would prevent them from getting psoriasis?"
Qureshi says that could be the case, which is why his study needs to be replicated. "You have to interpret the results cautiously because it is a single study," he says. "It is certainly possible that the women who exercise more are just more health-conscious. There could be other factors that could protect them from developing psoriasis."
Qureshi's study appears online in the Archives of Dermatology.
SOURCES: Qureshi, A. Archives of Dermatology, published online May 2012.Abrar Qureshi, MD, MPH, vice chair of dermatology at Brigham and Women's Hospital; assistant professor at Harvard Medical School, Boston.Siba Raychaudhuri, MD, University of California, Davis.Chris Ritchlin, MD, MPH, University of Rochester, New York.

Read More

Vigorous Exercise Might Protect Against Psoriasis

Click Here!
Women who engage in vigorous activities like running or aerobic exercise may have reduced risk of psoriasis


May 23, 2012 -- Here's yet another reason to exercise: A new study suggests that vigorous physical activity could reduce the risk of psoriasis.
The findings come out of the long-running Nurses' Health Study, which includes only women, but previous research suggests that exercise may also protect men against the chronic skin condition, characterized mostly by inflamed, scaly patches.
As many as 7.5 million Americans have psoriasis, according to the National Psoriasis Foundation, which says it's the most common autoimmune disease. Men and women are equally affected. Previous research has linked higher body mass index, or BMI, family history of psoriasis, alcohol use, and smoking to the risk of psoriasis.
In the new study, scientists followed nearly 87,000 female nurses for 14 years. None of them had been diagnosed with psoriasis at the beginning of the study. Over the course of the study, the nurses completed three detailed questionnaires about physical activity and were asked to report whether they were ever diagnosed with psoriasis. A total of 1,026 women said they were diagnosed during the study period and provided survey information about their physical activity.

Compared with no vigorous physical activity, vigorous exercise -- the equivalent of 105 minutes of running at a 6-mile-per-hour pace every week -- was associated with a 25% to 30% lower risk of psoriasis. The association remained significant after accounting for BMI, age, smoking, and alcohol use. The researchers say theirs is the first study to investigate the independent association between physical activity and psoriasis.
"The intensity of the exercise is the key," says researcher Abrar Qureshi, MD, MPH, vice chair of dermatology at Brigham and Women's Hospital and assistant professor at Harvard Medical School.
Only running and performing aerobic exercise or calisthenics were associated with a reduced risk of psoriasis. Other vigorous activities, such as jogging, playing tennis, swimming, and bicycling, were not. The researchers speculate that the highly variable intensity of the latter group of activities might account for the lack of an association with a lower psoriasis risk.
More than a decade ago, Siba Raychaudhuri, MD, reported that male and female psoriasis patients who exercised were likely to have less severe disease. "Walking was protective also," says Raychaudhuri, a rheumatologist at the University of California, Davis. He says he was "a little bit surprised" that Qureshi did not find that to be the case but added that "this study is more elegant than ours" because it collected more detailed information about exercise intensity.
Qureshi's team speculates that the lower risk of psoriasis in women who exercised vigorously might be due to a reduction in system-wide inflammation. Vigorous exercise also might be protective against psoriasis because it decreases anxiety and stress, which are tied to new cases and exacerbations of the disease, the researchers say.
"A good amount of data show that emotional stress reduction is good for psoriasis reduction," Raychaudhuri says.
Exposure to ultraviolet light is a psoriasis treatment, so time spent outdoors exercising, and not the exercise itself, might have explained the lowered risk of the disease, Qureshi says. But his study found that women who ran for only an hour a week had a significantly reduced risk of developing psoriasis than women who spent at least four hours walking outside at an average pace.
Chris Ritchlin, MD, MPH, a University of Rochester rheumatologist, calls Qureshi's findings "very interesting." Still, Ritchlin says, while exercise is known to be associated with reduced inflammation, "is there something about people who are really athletically inclined that we're not thinking about that would prevent them from getting psoriasis?"
Qureshi says that could be the case, which is why his study needs to be replicated. "You have to interpret the results cautiously because it is a single study," he says. "It is certainly possible that the women who exercise more are just more health-conscious. There could be other factors that could protect them from developing psoriasis."
Qureshi's study appears online in the Archives of Dermatology.
SOURCES: Qureshi, A. Archives of Dermatology, published online May 2012.Abrar Qureshi, MD, MPH, vice chair of dermatology at Brigham and Women's Hospital; assistant professor at Harvard Medical School, Boston.Siba Raychaudhuri, MD, University of California, Davis.Chris Ritchlin, MD, MPH, University of Rochester, New York.

Read More

Vigorous Exercise Might Protect Against Psoriasis

Click Here!
Women who engage in vigorous activities like running or aerobic exercise may have reduced risk of psoriasis


May 23, 2012 -- Here's yet another reason to exercise: A new study suggests that vigorous physical activity could reduce the risk of psoriasis.
The findings come out of the long-running Nurses' Health Study, which includes only women, but previous research suggests that exercise may also protect men against the chronic skin condition, characterized mostly by inflamed, scaly patches.
As many as 7.5 million Americans have psoriasis, according to the National Psoriasis Foundation, which says it's the most common autoimmune disease. Men and women are equally affected. Previous research has linked higher body mass index, or BMI, family history of psoriasis, alcohol use, and smoking to the risk of psoriasis.
In the new study, scientists followed nearly 87,000 female nurses for 14 years. None of them had been diagnosed with psoriasis at the beginning of the study. Over the course of the study, the nurses completed three detailed questionnaires about physical activity and were asked to report whether they were ever diagnosed with psoriasis. A total of 1,026 women said they were diagnosed during the study period and provided survey information about their physical activity.

Compared with no vigorous physical activity, vigorous exercise -- the equivalent of 105 minutes of running at a 6-mile-per-hour pace every week -- was associated with a 25% to 30% lower risk of psoriasis. The association remained significant after accounting for BMI, age, smoking, and alcohol use. The researchers say theirs is the first study to investigate the independent association between physical activity and psoriasis.
"The intensity of the exercise is the key," says researcher Abrar Qureshi, MD, MPH, vice chair of dermatology at Brigham and Women's Hospital and assistant professor at Harvard Medical School.
Only running and performing aerobic exercise or calisthenics were associated with a reduced risk of psoriasis. Other vigorous activities, such as jogging, playing tennis, swimming, and bicycling, were not. The researchers speculate that the highly variable intensity of the latter group of activities might account for the lack of an association with a lower psoriasis risk.
More than a decade ago, Siba Raychaudhuri, MD, reported that male and female psoriasis patients who exercised were likely to have less severe disease. "Walking was protective also," says Raychaudhuri, a rheumatologist at the University of California, Davis. He says he was "a little bit surprised" that Qureshi did not find that to be the case but added that "this study is more elegant than ours" because it collected more detailed information about exercise intensity.
Qureshi's team speculates that the lower risk of psoriasis in women who exercised vigorously might be due to a reduction in system-wide inflammation. Vigorous exercise also might be protective against psoriasis because it decreases anxiety and stress, which are tied to new cases and exacerbations of the disease, the researchers say.
"A good amount of data show that emotional stress reduction is good for psoriasis reduction," Raychaudhuri says.
Exposure to ultraviolet light is a psoriasis treatment, so time spent outdoors exercising, and not the exercise itself, might have explained the lowered risk of the disease, Qureshi says. But his study found that women who ran for only an hour a week had a significantly reduced risk of developing psoriasis than women who spent at least four hours walking outside at an average pace.
Chris Ritchlin, MD, MPH, a University of Rochester rheumatologist, calls Qureshi's findings "very interesting." Still, Ritchlin says, while exercise is known to be associated with reduced inflammation, "is there something about people who are really athletically inclined that we're not thinking about that would prevent them from getting psoriasis?"
Qureshi says that could be the case, which is why his study needs to be replicated. "You have to interpret the results cautiously because it is a single study," he says. "It is certainly possible that the women who exercise more are just more health-conscious. There could be other factors that could protect them from developing psoriasis."
Qureshi's study appears online in the Archives of Dermatology.
SOURCES: Qureshi, A. Archives of Dermatology, published online May 2012.Abrar Qureshi, MD, MPH, vice chair of dermatology at Brigham and Women's Hospital; assistant professor at Harvard Medical School, Boston.Siba Raychaudhuri, MD, University of California, Davis.Chris Ritchlin, MD, MPH, University of Rochester, New York.

Read More

Work-Related Asthma a Significant Problem: CDC

Click Here!THURSDAY, May 24 (HealthDay News) -- About nine percent of all asthma cases in the United States are caused or made worse by work-related exposures, a new federal study says.
That means work-related asthma affects about 1.4 million adults annually, the researchers said.

State-by-state rates of workplace-related asthma ranged from 4.8 percent (Arizona) to just over 14 percent (Florida), according to the study by researchers at the U.S. Centers for Disease Control and Prevention.
The analysis of 2006-09 data from 38 states and the District of Columbia also suggests that older workers and those in certain ethnic or minority groups are most at risk. For example, rates of employment-related asthma were 12.7 percent for people ages 45-64 vs. about 7 percent for people ages 18-44. Among racial groups rates of work-related asthma were 12.5 percent for blacks, 10.5 percent for Hispanics and 8.2 percent for whites, the report found.
The estimated proportion of adults with current asthma who had work-related asthma was similar for men and women, at about nine percent.
Asthma linked to on-the-job exposures is a preventable but under-recognized illness and the new findings highlight the need to expand workplace surveillance to better understand the risk factors and to better focus prevention efforts, the researchers said.
Better surveillance of the problem "would enhance our understanding of work-related asthma epidemiology and enable states, other government agencies, health professionals, employers, workers and worker representatives to better target intervention efforts to reduce the burden of work-related asthma," the researchers wrote in a summary.
The study appears in the May 25 issue of the CDC's Morbidity and Mortality Weekly Report.

Read More

Work-Related Asthma a Significant Problem: CDC

Click Here!THURSDAY, May 24 (HealthDay News) -- About nine percent of all asthma cases in the United States are caused or made worse by work-related exposures, a new federal study says.
That means work-related asthma affects about 1.4 million adults annually, the researchers said.

State-by-state rates of workplace-related asthma ranged from 4.8 percent (Arizona) to just over 14 percent (Florida), according to the study by researchers at the U.S. Centers for Disease Control and Prevention.
The analysis of 2006-09 data from 38 states and the District of Columbia also suggests that older workers and those in certain ethnic or minority groups are most at risk. For example, rates of employment-related asthma were 12.7 percent for people ages 45-64 vs. about 7 percent for people ages 18-44. Among racial groups rates of work-related asthma were 12.5 percent for blacks, 10.5 percent for Hispanics and 8.2 percent for whites, the report found.
The estimated proportion of adults with current asthma who had work-related asthma was similar for men and women, at about nine percent.
Asthma linked to on-the-job exposures is a preventable but under-recognized illness and the new findings highlight the need to expand workplace surveillance to better understand the risk factors and to better focus prevention efforts, the researchers said.
Better surveillance of the problem "would enhance our understanding of work-related asthma epidemiology and enable states, other government agencies, health professionals, employers, workers and worker representatives to better target intervention efforts to reduce the burden of work-related asthma," the researchers wrote in a summary.
The study appears in the May 25 issue of the CDC's Morbidity and Mortality Weekly Report.

Read More

Work-Related Asthma a Significant Problem: CDC

Click Here!THURSDAY, May 24 (HealthDay News) -- About nine percent of all asthma cases in the United States are caused or made worse by work-related exposures, a new federal study says.
That means work-related asthma affects about 1.4 million adults annually, the researchers said.

State-by-state rates of workplace-related asthma ranged from 4.8 percent (Arizona) to just over 14 percent (Florida), according to the study by researchers at the U.S. Centers for Disease Control and Prevention.
The analysis of 2006-09 data from 38 states and the District of Columbia also suggests that older workers and those in certain ethnic or minority groups are most at risk. For example, rates of employment-related asthma were 12.7 percent for people ages 45-64 vs. about 7 percent for people ages 18-44. Among racial groups rates of work-related asthma were 12.5 percent for blacks, 10.5 percent for Hispanics and 8.2 percent for whites, the report found.
The estimated proportion of adults with current asthma who had work-related asthma was similar for men and women, at about nine percent.
Asthma linked to on-the-job exposures is a preventable but under-recognized illness and the new findings highlight the need to expand workplace surveillance to better understand the risk factors and to better focus prevention efforts, the researchers said.
Better surveillance of the problem "would enhance our understanding of work-related asthma epidemiology and enable states, other government agencies, health professionals, employers, workers and worker representatives to better target intervention efforts to reduce the burden of work-related asthma," the researchers wrote in a summary.
The study appears in the May 25 issue of the CDC's Morbidity and Mortality Weekly Report.

Read More

Yoga May Improve Symptoms of Rheumatoid Arthritis

People With Rheumatoid Arthritis Feel Better After 6 Weeks of Iyengar-Style Yoga

Click Here!

WebMD Health News
Reviewed by Laura J. Martin, MD
May 24, 2012 (Honolulu, Hawaii) -- Young patients with rheumatoid arthritis (RA) may feel better after practicing yoga for just six weeks, a new study shows.
Researchers reported their findings here last week at the American Pain Society's annual meeting.
"It seems to be a very feasible, practical treatment for patients with rheumatoid arthritis," one of the researchers, Kirsten Lung, tells WebMD. Lung researches pain at the University of California, Los Angeles (UCLA).
The results are not surprising to Kathleen Sluka, PhD, a physical therapist who researches pain at the University of Iowa. All kinds of physical activity can help with rheumatoid arthritis, she tells WebMD. Sluka was not involved in this study.
RA is a chronic type of arthritis. It is an autoimmune disease. It is most common among women. Early symptoms include fatigue, joint pain, and stiffness.
As it progresses, RA may feel like the flu, with muscle aches and loss of appetite. Early and effective treatment may help prevent joint and bone destruction.
The UCLA researchers say some drugs for RA can pose additional risks for younger patients. So the researchers are looking for alternatives. They decided to try Iyengar yoga.
In Iyengar yoga, practitioners may use blocks, straps, cushions, and other props to stretch and strengthen their muscles.
The UCLA researchers recruited 26 women with RA. The women's ages ranged from 21 to 35. On average they had suffered from RA for 10 and a half years.
The researchers then assigned 11 of these women to classes in Iyengar yoga. They assigned the other 15 to a wait list for yoga classes.
After six weeks, they asked both groups about their condition. The group that practiced yoga said they were happier than when they started. They said they could better accept their pain. They also reported better general health and more energy.
The women on the wait list for yoga classes did not experience these improvements.
Even the women who did yoga did not report less pain or disability. That may be because the study was so short, says Lung. "But six weeks did a world of good for those involved."
Sluka says that physical exercise usually takes about eight weeks to show significant effects. All kinds of exercise can help with RA, she says. "Yoga is just another form of exercise," she says.
By strengthening muscles, exercise prevents joints from moving in uncomfortable ways. And it can activate parts of the nervous system that reduce pain.
The study is not conclusive, she points out, because it is very small. Also, there is a possibility that the people in the yoga group felt better just because they were doing something to help themselves, not specifically because they were doing yoga.
But the study is still worthwhile, Sluka says. It shows people with RA they have another option for getting exercise. "Some people like to run. Some people like to lift weights. Some people like to do yoga," she says.
These findings were presented at a medical conference. They should be considered preliminary, as they have not yet undergone the "peer review" process, in which outside experts scrutinize the data prior to publication in a medical journal.
SOURCES: 31st Annual Scientific Meeting of the American Pain Society, Honolulu, Hawaii, May 16-19, 2012.Kirsten Lung, research associate, University of California, Los Angeles Pediatric Pain Program.Kathleen Sluka, professor of physical therapy & rehabilitation science, University of Iowa.

Read More

Where to Find the Best Food Souvenirs in Paris

AppId is over the quota
AppId is over the quota

By Jennifer Ladonne

It may be known as the romantic City of Light and the capital of haute couture, but if there's one thing every traveler yearns to bring home after a trip to Paris, it's a souvenir of the tastes and sips the city offers. From classic choices like a box of delicate, pastel-colored macarons and rich, creamy chocolate truffles to more unique bites like 12th century candies and sweet and savory confitures, there are endless foodstuffs to bring home. Here are some of the best spots to find them across the city.

Sweets at Le Bonbon au Palais trace the map of France—cocquelicots de Nemours, niniches de Quiberon, mirabelles de Lorraine—all tantalizingly displayed in shapely glass jars. Of the 650 bonbons considered part of France's historic legacy, 200 handpicked varieties can be found here, and only those that have been continuously produced by the original artisanal manufacturers. The most ancient example, made of licorice and honey, dates back to the 12th century, when the pearly drops doubled as currency on pilgrimage routes. The bonbons are sold by weight, so you can easily sample them all.

Don't Miss: Candied flowers, fluffy guimauves (traditional marshmallows) in flavors like bergamot and banana, liqueur-filled marzipan enrobed chocolates, and candied blueberries and currents, which may not outdo Mother Nature but sure come close.

French-Belgian patisserie Meert dates back to 1761 and was named official supplier to King Leopold I of Belgium in 1864. Makers of the gaufre, a golden waffle native to Flanders, Meert's recipe is held a strict secret and is treasured for its light cream center perfumed with Madagascar vanilla. The first Paris branch imports the tender, lozenge-shaped pastries daily from Lille, where they are still made by hand over a wood fire. Individually wrapped and beautifully packaged in boxes of six, the gaufres will last up to a week.

Insider Tip: Visit on a Saturday to sample the specialty pastries delivered once a week from Lille. Speculos gaufres, a traditional cinnamon and spice blend, are available for three weeks at Easter time.

The newest addition to the many gourmet shops on the famous market street rue des Martyrs is the sleek and airy La Chambre aux Confitures. Besides dozens of varieties of fruit preserves, including flavors like mirabelle plum, apricot lavender, and strawberry rose, there are marmalades, gelées, and chutneys galore. Hard-to-find gourmet confitures meant for cheese and foie gras—fig, olive and hazelnut; roasted apple and calvados; onion, Beaujolais and Cassis—provide a lesson in French gourmandise. Preserves are made with hand-chosen fruits and a minimal amount of sugar. Best of all, there are spoons for sampling.

Don't Miss: Pale green gelées florales of basil, rosemary, or thyme flowers or a honey-and-pine-bud version that will thrill your gourmet friends. Chocoholics will love the dozen sublime concoctions to spoon over ice cream—or fingers.

Once hidden behind an unmarked door known only to chefs and aficionados, virtuoso chocolatier-patissier Jacques Genin opened his Marais boutique a few years back to euphoric reviews. Renowned for their delicately perfumed ganaches made with fresh, seasonal ingredients, the chocolates are handmade daily on the premises, along with velvety caramels, fruit patés, and Genin's masterful take on the classic French pastries—the Paris Brest, éclair, and a heavenly (award-winning) mille-feuille. Beautiful magnetic tins make the chocolates, which last up to three weeks, easy to transport and beautiful to offer.

Insider Tip: Everything can be sampled in the boutique's elegant modern tearoom.

One of Paris's oldest wine stores, Caves Auge is also its most atmospheric. Crammed floor to ceiling with examples of the best wines France has to offer, along with a choice selection of French cognacs and Armagnac, it's a wine lover's paradise. A knowledgeable, English-speaking staff and handsome gift boxes with the store's insignia make gift shopping a breeze. And if you're very lucky you'll meet tout Paris at one of the famous wine tastings, set out on huge wine barrels on the front sidewalk on Saturdays in the fall and spring (check online for schedule).

Insider Tip: Augé's fall Champagne degustations are the toast of the town, where you can sample small-producer bubbles that can't be found stateside, along with the expensive grand marques. If you can't make it, all the Champagnes are stocked in the store.

If time is short and your gift list long, head over to La Grand Epicerie, Paris's largest gourmet grocery (conveniently attached to the elegant Bon Marché department store). The store's dizzying array of everything from gourmet teas to fresh foie gras has something for everyone. Easily navigable departments include chocolate and candies, coffee and tea, spices, confitures, patés, cheeses, a superb wine shop, get the picture?

Insider Tip: It's a one-stop shop for picnic food or lunch on the fly. Freshly prepared salads, dozens of sandwiches, paninis, cut fruit, specialty dishes, and bottled drinks are conveniently packaged and ready to go.

For up-to-the-minute restaurant and hotel recommendations, as well as the best planning advice, check out our Paris Travel Guide.

Photo credits: Le Bonbon au Palais courtesy of Jennifer Ladonne; Meert courtesy of Meert; Caves Auges via Flickr/Josh Clark; Eclairs via Flickr/roboppy

View the original article here

Read More

Evolutionary Molecular Medicine

AppId is over the quota AppId is over the quota

Abstract

Evolution has long provided a foundation for population genetics, but some major advances in evolutionary biology from the twentieth century that provide foundations for evolutionary medicine are only now being applied in molecular medicine. They include the need for both proximate and evolutionary explanations, kin selection, evolutionary models for cooperation, competition between alleles, co-evolution, and new strategies for tracing phylogenies and identifying signals of selection. Recent advances in genomics are transforming evolutionary biology in ways that create even more opportunities for progress at its interfaces with genetics, medicine, and public health. This article reviews 15 evolutionary principles and their applications in molecular medicine in hopes that readers will use them and related principles to speed the development of evolutionary molecular medicine.

Posted in evolutionary medicine

 

Read More

Evolutionary Molecular Medicine

AppId is over the quota AppId is over the quota

Abstract

Evolution has long provided a foundation for population genetics, but some major advances in evolutionary biology from the twentieth century that provide foundations for evolutionary medicine are only now being applied in molecular medicine. They include the need for both proximate and evolutionary explanations, kin selection, evolutionary models for cooperation, competition between alleles, co-evolution, and new strategies for tracing phylogenies and identifying signals of selection. Recent advances in genomics are transforming evolutionary biology in ways that create even more opportunities for progress at its interfaces with genetics, medicine, and public health. This article reviews 15 evolutionary principles and their applications in molecular medicine in hopes that readers will use them and related principles to speed the development of evolutionary molecular medicine.

Posted in evolutionary medicine

 

Read More

Evolutionary Molecular Medicine

AppId is over the quota AppId is over the quota

Abstract

Evolution has long provided a foundation for population genetics, but some major advances in evolutionary biology from the twentieth century that provide foundations for evolutionary medicine are only now being applied in molecular medicine. They include the need for both proximate and evolutionary explanations, kin selection, evolutionary models for cooperation, competition between alleles, co-evolution, and new strategies for tracing phylogenies and identifying signals of selection. Recent advances in genomics are transforming evolutionary biology in ways that create even more opportunities for progress at its interfaces with genetics, medicine, and public health. This article reviews 15 evolutionary principles and their applications in molecular medicine in hopes that readers will use them and related principles to speed the development of evolutionary molecular medicine.

Posted in evolutionary medicine

 

Read More

'Gangster Squad' Trailer: Ryan Gosling, Emma Stone Reunite In 1940s Action Drama

AppId is over the quota
AppId is over the quota

It's the on-screen reunion you never thought you were waiting for! Since seeing his "photoshopped" abs in last year's "Crazy Stupid Love," Emma Stone is back together again with Ryan Gosling.

In the first trailer for their shoot-em-up crime drama "Gangster Squad," Stone and Gosling are once again unlikely paramours -- she's arm candy for Mickey Cohen (Sean Penn), the most feared mobster in LA, and he's an LAPD officer.

From director Ruben Fleischer ("Zombieland"), "Gangster Squad" follows a group of 1940s rouge cops who will stop at nothing to catch L.A.'s most wanted (Penn). The film is based on Paul Lieberman's Los Angeles Times series "Tales From The Gangster Squad," and boasts quite a bit of star power: In addition to Stone, Penn and Gosling, the rest of cast includes Josh Brolin, Anthony Mackie, Giovanni Ribisi, Robert Patrick and Nick Nolte.

Check out the newly released trailer above.

"Gangster Squad" hits theaters later this year.

[via Apple]

PHOTOS:
'>

"We get down, if the play calls for it, bud." Say what you will about Michael Mann's overwrought, ultra-stylized "Miami Vice" ("Drive" before "Drive"?), but its Jay-Z-fueled trailer was just about perfect.

not prove it either. Just sayin'." data-credits="" data-height="0" data-width="0" data-title_link="Heart_Of_The" data-slideimage_id="676934" data-image_urls='["http:\/\/i.huffpost.com\/gadgets\/slideshows\/208462\/slide_208462_676934_free.jpg","http:\/\/i.huffpost.com\/gadgets\/slideshows\/208462\/slide_208462_676934_huge.jpg","http:\/\/i.huffpost.com\/gadgets\/slideshows\/208462\/slide_208462_676934_large.jpg"]' data-thumb_urls='["http:\/\/i.huffpost.com\/gadgets\/slideshows\/208462\/slide_208462_676934_sq50.jpg","http:\/\/i.huffpost.com\/gadgets\/slideshows\/208462\/slide_208462_676934_small.jpg"]' data-display_domain="http://i.huffpost.com/" data-video=''>

You can't prove that "American Gangster" -- an R-rated, two-and-a-half hour drama -- opened with $43 million solely because Universal used "Heart of the City" in the trailer, but you can't not prove it either. Just sayin'.

reminder (groan) that "The Hangover Part II" was just a pale retread of "The Hangover," the marketing campaign used Jay-Z's "Reminder" to score many of the spots and trailers. At least the song is good." data-credits="" data-height="0" data-width="0" data-title_link="Reminder_The_Hangover" data-slideimage_id="676935" data-image_urls='["http:\/\/i.huffpost.com\/gadgets\/slideshows\/208462\/slide_208462_676935_free.jpg","http:\/\/i.huffpost.com\/gadgets\/slideshows\/208462\/slide_208462_676935_huge.jpg","http:\/\/i.huffpost.com\/gadgets\/slideshows\/208462\/slide_208462_676935_large.jpg"]' data-thumb_urls='["http:\/\/i.huffpost.com\/gadgets\/slideshows\/208462\/slide_208462_676935_sq50.jpg","http:\/\/i.huffpost.com\/gadgets\/slideshows\/208462\/slide_208462_676935_small.jpg"]' data-display_domain="http://i.huffpost.com/" data-video=''>

As if you needed another reminder (groan) that "The Hangover Part II" was just a pale retread of "The Hangover," the marketing campaign used Jay-Z's "Reminder" to score many of the spots and trailers. At least the song is good.

'>

Nothing says "edgy" conflict like "99 Problems." In addition to this early spot for "This Means War," the song also pops up in "Taking of Pelham 1 2 3" and "Tower Heist."

chorale version of "Creep" that was used to expertly in the first trailers, Kanye West's "Power" had its own affect on the Facebook movie. After all, even nerds look cool when Kanye is blasting. (Also used in "Limitless.")" data-credits="" data-height="0" data-width="0" data-title_link="Power_The_Social" data-slideimage_id="676941" data-image_urls='["http:\/\/i.huffpost.com\/gadgets\/slideshows\/208462\/slide_208462_676941_free.jpg","http:\/\/i.huffpost.com\/gadgets\/slideshows\/208462\/slide_208462_676941_huge.jpg","http:\/\/i.huffpost.com\/gadgets\/slideshows\/208462\/slide_208462_676941_large.jpg"]' data-thumb_urls='["http:\/\/i.huffpost.com\/gadgets\/slideshows\/208462\/slide_208462_676941_sq50.jpg","http:\/\/i.huffpost.com\/gadgets\/slideshows\/208462\/slide_208462_676941_small.jpg"]' data-display_domain="http://i.huffpost.com/" data-video=''>

Not as tied to "The Social Network" as that chorale version of "Creep" that was used to expertly in the first trailers, Kanye West's "Power" had its own affect on the Facebook movie. After all, even nerds look cool when Kanye is blasting. (Also used in "Limitless.")

'>

The song might be all New York, but the movie was not. "Sex and the City 2" sent Carrie, Samantha, Miranda and Charlotte to Abu Dhabi. Obviously.

'>

"In the immortal words of Jay-Z." Yep, see you at the theater this summer!

'>

An inspirational sports drama that relied on its score and some period appropriate '80s and '90s music, the television spots for "The Fighter" trotted out "Run This Town." The results? Kinda awesome, actually.

'>

Even the Borat-y jokes in the trailer for "The Dictator" look better with Jay-Z blaring on the soundtrack. Well played, Paramount marketing team!

a lot. Remember "American Gangster"?' data-credits="" data-height="0" data-width="0" data-title_link="No_Church_in" data-slideimage_id="676927" data-image_urls='["http:\/\/i.huffpost.com\/gadgets\/slideshows\/208462\/slide_208462_676927_free.jpg","http:\/\/i.huffpost.com\/gadgets\/slideshows\/208462\/slide_208462_676927_huge.jpg","http:\/\/i.huffpost.com\/gadgets\/slideshows\/208462\/slide_208462_676927_large.jpg"]' data-thumb_urls='["http:\/\/i.huffpost.com\/gadgets\/slideshows\/208462\/slide_208462_676927_sq50.jpg","http:\/\/i.huffpost.com\/gadgets\/slideshows\/208462\/slide_208462_676927_small.jpg"]' data-display_domain="http://i.huffpost.com/" data-video=''>

For the Denzel Washington-Ryan Reynolds action flick (out Friday), Universal used the "Watch the Throne" hit "No Church in the Wild." How much money this will add to the coffers remains to be seen, but the guess here is a lot. Remember "American Gangster"?

Get Alerts

View the original article here

Read More

'Moonrise Kingdom': Go Behind The Scenes Of Wes Anderson's New Film

AppId is over the quota
AppId is over the quota

Behold, a Wes Anderson-styled behind-the-scenes featurette from a new Wes Anderson film!

In this exclusive clip from his upcoming movie, "Moonrise Kingdom," fans get a closer look at tough-guy Bruce Willis in a very non-tough-guy role (a nice local cop named Captain Sharp). Narrated by Bob Balaban, the video shows Willis taking on big actor stuff: Driving! Running! Fake rain! However, that part where he hangs upside-down? That wasn't Bruce. It was -- as Balaban explains -- a stunt double. You can check it all out in the video above.

Set in 1960s New England, "Moonrise Kingdom" tells the story of Sam (Jared Gilman), a young boy who runs away from home with childhood crush Suzy (Kara Hayward). Heading up the rescue effort is Sharp (Willis), Scout Master Ward (Ed Norton), Laura Bishop (Frances McDormand) and her husband, Walt (Bill Murray). The film hits theaters on May 25.

Several other sites premiered their own "Moonrise" featurettes, which you can see below.

MTV Movies
Fandango
Yahoo! Movies

PHOTOS
[{"entry_id":"1455946","entry_url":"http:\/\/news.moviefone.com\/2012\/04\/26\/mpaa-system-movie-theater-rules_n_1455946.html","content_type":"video","image_url":"gadgets\/slideshows\/222853\/slide_222853_909752_small.jpg","thumbnail_url":"gadgets\/slideshows\/222853\/slide_222853_909752_small.jpg","title":"MPAA System: 9 Ridiculous Things Hollywood Tried To Ban In 1927","slideshow_id":"222853","vertical":"moviefone"},{"entry_id":"1455146","entry_url":"http:\/\/news.moviefone.com\/2012\/04\/26\/romcom-dos-and-donts_n_1455146.html","content_type":"video","image_url":"gadgets\/slideshows\/222616\/slide_222616_905040_small.jpg","thumbnail_url":"gadgets\/slideshows\/222616\/slide_222616_905040_small.jpg","title":"Romantic Comedy Dos And Don'ts: The Pitfalls Of The Rom-Com Genre (VIDEOS)","slideshow_id":"222616","vertical":"moviefone"},{"entry_id":"1422241","entry_url":"http:\/\/news.moviefone.com\/2012\/04\/12\/the-three-stooges-reviews-critic-reactions_n_1422241.html","content_type":"image","image_url":"gadgets\/slideshows\/220334\/slide_220334_866407_small.jpg","thumbnail_url":"gadgets\/slideshows\/220334\/slide_220334_866407_small.jpg","title":"'The Three Stooges' Reviews: Critics React Favorably To Film","slideshow_id":"220334","vertical":"moviefone"},{"entry_id":"1421937","entry_url":"http:\/\/news.moviefone.com\/2012\/04\/12\/the-three-stooges-catholic-league-nun-bikini_n_1421937.html","content_type":"image","image_url":"gadgets\/slideshows\/211641\/slide_211641_735597_small.jpg","thumbnail_url":"gadgets\/slideshows\/211641\/slide_211641_735597_small.jpg","title":"'Three Stooges': Catholic League Criticizes Comedy Movie's Swimsuit-Wearing Nun","slideshow_id":"211641","vertical":"moviefone"},{"entry_id":"1477452","entry_url":"http:\/\/news.moviefone.com\/2012\/05\/04\/2012-summer-movie-preview-indie-films_n_1477452.html","content_type":"image","image_url":"gadgets\/slideshows\/224445\/slide_224445_939028_small.jpg","thumbnail_url":"gadgets\/slideshows\/224445\/slide_224445_939028_small.jpg","title":"2012 Summer Movie Preview: Indie Films","slideshow_id":"224445","vertical":"moviefone"},{"entry_id":"1432664","entry_url":"http:\/\/news.moviefone.com\/2012\/04\/17\/best-movies-to-watch-high_n_1432664.html","content_type":"video","image_url":"gadgets\/slideshows\/220832\/slide_220832_875216_small.jpg","thumbnail_url":"gadgets\/slideshows\/220832\/slide_220832_875216_small.jpg","title":"Best Movies To Watch High: Stoner Movies For 4\/20 (VIDEO)","slideshow_id":"220832","vertical":"moviefone"},{"entry_id":"1446248","entry_url":"http:\/\/news.moviefone.com\/2012\/04\/23\/married-couples-in-movies_n_1446248.html","content_type":"video","image_url":"gadgets\/slideshows\/222060\/slide_222060_896458_small.jpg","thumbnail_url":"gadgets\/slideshows\/222060\/slide_222060_896458_small.jpg","title":"Married Couples In Movies: Spouses Who've Appeared In The Same Film","slideshow_id":"222060","vertical":"moviefone"},{"entry_id":"1470092","entry_url":"http:\/\/news.moviefone.com\/2012\/05\/02\/2012-summer-movie-preview-family-films_n_1470092.html","content_type":"image","image_url":"gadgets\/slideshows\/223812\/slide_223812_927505_small.jpg","thumbnail_url":"gadgets\/slideshows\/223812\/slide_223812_927505_small.jpg","title":"2012 Summer Movie Preview: Family Films","slideshow_id":"223812","vertical":"moviefone"},{"entry_id":"1504432","entry_url":"http:\/\/news.moviefone.com\/2012\/05\/09\/thomas-crown-affair-cast-faye-dunaway_n_1504432.html","content_type":"image","image_url":"gadgets\/slideshows\/225534\/slide_225534_960445_small.jpg","thumbnail_url":"gadgets\/slideshows\/225534\/slide_225534_960445_small.jpg","title":"'The Thomas Crown Affair': A Look Back At The Classic Caper","slideshow_id":"225534","vertical":"moviefone"},{"entry_id":"1505818","entry_url":"http:\/\/news.moviefone.com\/2012\/05\/10\/gangster-squad-trailer-ryan-gosling-emma-stone_n_1505818.html","content_type":"video","image_url":"gadgets\/slideshows\/208462\/slide_208462_676929_small.jpg","thumbnail_url":"gadgets\/slideshows\/208462\/slide_208462_676929_small.jpg","title":"'Gangster Squad' Trailer: Ryan Gosling, Emma Stone Reunite In 1940s Action Drama","slideshow_id":"208462","vertical":"moviefone"},{"entry_id":"1509798","entry_url":"http:\/\/news.moviefone.com\/2012\/05\/11\/mothers-day-best-movie-moms_n_1509798.html","content_type":"image","image_url":"gadgets\/slideshows\/225915\/slide_225915_966853_small.jpg","thumbnail_url":"gadgets\/slideshows\/225915\/slide_225915_966853_small.jpg","title":"Mother's Day: Best Movie Moms, From Mrs. Gump To Molly Weasley","slideshow_id":"225915","vertical":"moviefone"},{"entry_id":"1457278","entry_url":"http:\/\/news.moviefone.com\/2012\/04\/26\/avengers-comics-movie-guide_n_1457278.html","content_type":"image","image_url":"gadgets\/slideshows\/222958\/slide_222958_911493_small.jpg","thumbnail_url":"gadgets\/slideshows\/222958\/slide_222958_911493_small.jpg","title":"'Avengers' Comics: Where To Start Before You Watch Marvel's Superhero Movie","slideshow_id":"222958","vertical":"moviefone"},{"entry_id":"1475996","entry_url":"http:\/\/news.moviefone.com\/2012\/05\/03\/biggest-movie-plot-holes_n_1475996.html","content_type":"image","image_url":"gadgets\/slideshows\/224366\/slide_224366_937661_small.jpg","thumbnail_url":"gadgets\/slideshows\/224366\/slide_224366_937661_small.jpg","title":"Biggest Movie Plot Holes: 'Superman,' 'Edward Scissorhands,' 'Ocean's 11'","slideshow_id":"224366","vertical":"moviefone"},{"entry_id":"1500373","entry_url":"http:\/\/news.moviefone.com\/2012\/05\/08\/mothers-day-gift-guide-movies_n_1500373.html","content_type":"image","image_url":"gadgets\/slideshows\/225137\/slide_225137_952892_small.jpg","thumbnail_url":"gadgets\/slideshows\/225137\/slide_225137_952892_small.jpg","title":"Mother's Day Movie Gift Guide: DVD Box Sets Mama Will Love (PHOTOS)","slideshow_id":"225137","vertical":"moviefone"},{"entry_id":"1459673","entry_url":"http:\/\/news.moviefone.com\/2012\/04\/27\/summer-movies-2012-action_n_1459673.html","content_type":"image","image_url":"gadgets\/slideshows\/222939\/slide_222939_911213_small.jpg","thumbnail_url":"gadgets\/slideshows\/222939\/slide_222939_911213_small.jpg","title":"2012 Summer Movie Preview: Action And Sci-Fi","slideshow_id":"222939","vertical":"moviefone"},{"entry_id":"1497592","entry_url":"http:\/\/news.moviefone.com\/2012\/05\/07\/avengers-2-sequel-predictions_n_1497592.html","content_type":"image","image_url":"gadgets\/slideshows\/224904\/slide_224904_948165_small.jpg","thumbnail_url":"gadgets\/slideshows\/224904\/slide_224904_948165_small.jpg","title":"'Avengers 2': Predicting The Plot And Characters Of The Marvel Superhero Sequel","slideshow_id":"224904","vertical":"moviefone"},{"entry_id":"1475500","entry_url":"http:\/\/news.moviefone.com\/2012\/05\/03\/2012-summer-movie-preview-comedy_n_1475500.html","content_type":"image","image_url":"gadgets\/slideshows\/223996\/slide_223996_930348_small.jpg","thumbnail_url":"gadgets\/slideshows\/223996\/slide_223996_930348_small.jpg","title":"2012 Summer Movie Preview: Comedy","slideshow_id":"223996","vertical":"moviefone"},{"entry_id":"1435789","entry_url":"http:\/\/news.moviefone.com\/2012\/04\/18\/favorite-new-york-films-manhattan_n_1435789.html","content_type":"video","image_url":"gadgets\/slideshows\/221504\/slide_221504_886360_small.jpg","thumbnail_url":"gadgets\/slideshows\/221504\/slide_221504_886360_small.jpg","title":"Best New York Movie: 'Manhattan' And 'Sex And The City' Tied For Winner","slideshow_id":"221504","vertical":"moviefone"}] Get Alerts

View the original article here

Read More