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Monday, July 2, 2012

PRESS DIGEST-Financial Times-July 2

London, 2 July | Sunday 1 July 2012 9:14 pm EDT

London, July 2 (Reuters)-Financial Times headlines AGIUS to exit on LIBOR Coalition scandal puts HEATHROW decision on ice rating agencies face gilt auctions probe to be put ON HOLD for Olympics reviews VODAFONE MCLAREN F1 sponsorship automotive clash on European emissions L & G to offer SOCIAL HOUSING loans ASTRAZENECA eyes more deals after AMYLIN

Overview AGIUS to exit on LIBOR scandal Marcus Agius will resign as President of Barclays on Monday in the hope that his departure will take the sting out of criticism from politicians and shareholders to mounting on the Bank's role in fixing of interbank lending rates.

COALITION puts HEATHROW decision on the ice that the ruling coalition is planning to delay a decision on increasing airport capacity in the South East of England until after the next general election.

Credit rating agencies face probe The European markets watchdog is investigating whether the methods of credit rating agencies evaluating the three major banks are quite transparent and rigorous, its President Steven Maijoor said in an interview.

GILT auctions to be put ON HOLD for the Olympics the United Kingdom Treasury has called off its weekly gilt auctions for a period of four weeks between mid-July and mid-August, apparently because it fears that too many bond traders will be working from home-or at all-as Vodafone Olympics. VODAFONE reviews MCLAREN F1 sponsorship is reviewing its global sports and sponsorship of events including title sponsorship of McLaren Formula 1.

European carmakers ' row ON emissions fight has erupted between manufacturers of premium of Germany and their French and Italian competitors over the formula used by the European Commission to grant long-term objectives of CO2-cutting producers.

L & G to offer SOCIAL HOUSING loans insurance legal General & is to start providing loans to housing associations, the latest example of a new lender moving to exploit the lack of bank finance for real estate.

ASTRAZENECA eyes more deals after AMYLIN AstraZeneca has money and appetite for more acquisitions, the acting head of the Anglo-Swedish pharmaceutical group said after his purchase innovative joint $ 7 billions of Amylin with Bristol-Myers Squibb over the weekend finalising.


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NLM invites nominations for IHTSDO standing committees due June 29, 2012

Call for nominations: As a member of the International Health terminology standards development organization (IHTSDO) of the United States, the National Library of Medicine (NLM) is soliciting nominations of potential candidates for four standing committees – IHTSDO content, Quality Assurance, technical innovation and & implementation. These committees have important roles in the ongoing development of the SYSTEMATIZED NOMENCLATURE of MEDICINE clinical terminology CT and IHTSDO. Nominations are due to NLM by COB June 29, 2012 (see details below).

The current roster, terms of reference and recent reports of each Committee are available on the IHTSDO. The committees are described in section 9.4-9.9 of the articles of the IHTSDO.

About half of the 12 members of each Standing Committee serve terms that expire in December 2012. People elected to these slots will serve for 2 years (Jan. 2013-December 2014). There may be additional Committee vacancies caused by resignation. The chosen people to fill these slots will serve intermediate for 1 year (Jan-Dec 2013).

Whose terms are expiring the members of the Committee are eligible for quit the Committee itself, provided they have served more than six consecutive years of the Committee of the regions.  Quit the Committee itself is possible after sitting out a minimum of one year from the date on which that have left the Committee.  There is no impediment to a Committee member leaving a Committee and being appointed to another.  Eligible for quit the Committee members must submit a nomination package (see details below).

As A result of changes made to articles approved in April 2009 IHTSDO, most positions on each Committee is at-large seats and can be filled by people appointed by IHTSDO members from any geographical region.  Currently the region the Americas includes the United States and Canada.

Procedure for appointment of United States: All United States affiliate licensees SYSTEMATIZED NOMENCLATURE of MEDICINE CT (aka, all United States UMLS licensees) can vote to select candidates U.S. IHTSDO committees. Is the timeline for the nominations and elections:

4 June – 29 June: NLM accepts nominations of potential candidates for the four permanent committees of IHTSDO. Will be only accepted applicants with complete nomination packages (see below for details and the necessary forms). 16 July – 17 August: U.S. SYSTEMATIZED NOMENCLATURE of MEDICINE CT Affiliates cast votes for candidates for top three for each Standing Committee. Instructions for casting ballots will be sent to U.S. affiliates the SYSTEMATIZED NOMENCLATURE of MEDICINE CT 16 July. For each Committee, the three candidates receiving the most votes will become U.S. candidates for the Committee. 1 September 2012: NLM will submit the names of three candidates 3 receives the most votes as candidates for each of the four committees of IHTSDO for consideration by the General Assembly of the IHTSDO. 22-26 October 2012: IHTSDO will announce the final results of the election process in the General Assembly to be held in conjunction with the community of practice meeting of IHTSDO.

Obligations and participation Committee logistics: English is the official language of IHTSDO, but Commission members must be willing to take additional measures to ensure understanding by those for whom English is a second language. Teleconference agreements are available for all meetings of the Committee, but, given the geographical distribution of IHTSDO members (currently Australia, Canada, Cyprus, Denmark, Estonia, Iceland, Israel, Lithuania, Malta, New Zealand, Poland, Singapore, Slovak Republic, Slovenia, Spain, Sweden, Netherlands, United Kingdom and United States), meeting timetables may not be affordable to all relevant zones. The IHTSDO encourages the members of the Committee to participate in at least one of the two main meetings annually in person IHTSDO. For the members of the Committee of the United States that need assistance to face-to-face meetings, NLM will travel to a meeting of IHTSDO per year. Committee members should participate (in person or via teleconference) at least 50% of their Committee meetings to keep their seat on the Committee. Members of the Committee of the United States may be called upon to provide input and advice on issues relating to the NLM IHTSDO and SYSTEMATIZED NOMENCLATURE of MEDICINE CT.

Submit your application: Nominations are due to NLM by COB June 29, 2012. Please send nomination packages to NLM via email (nichsr@nlm.nih.gov) with the subject line "We nominated – IHTSDO standing committees". Each nomination package must include:

Nomination form (PDF, Word) completed 1 page mini curriculum vitae highlighting the key sectors of the candidate's experience and expertise page 1 Declaration of interest outlining why the candidate is suitable for the particular Board in question and because the candidate feels that the Committee's work are important. Note: applications must be for a specific Commission. Completed an array of skills for the competent Committee that summarizes key aspects of the proposed background content (PDF, Word) quality assurance (PDF, Word) implementation and innovation (PDF, Word) technical (PDF, Word) completed Declaration of interest (PDF, Word)

Individuals may nominate themselves. Questions about the application process should be sent to nichsr@nlm.nih.gov, please include the subject line "We nominated – IHTSDO standing committees".


View the original article here

NLM invites nominations for IHTSDO standing committees due June 29, 2012

Call for nominations: As a member of the International Health terminology standards development organization (IHTSDO) of the United States, the National Library of Medicine (NLM) is soliciting nominations of potential candidates for four standing committees – IHTSDO content, Quality Assurance, technical innovation and & implementation. These committees have important roles in the ongoing development of the SYSTEMATIZED NOMENCLATURE of MEDICINE clinical terminology CT and IHTSDO. Nominations are due to NLM by COB June 29, 2012 (see details below).

The current roster, terms of reference and recent reports of each Committee are available on the IHTSDO. The committees are described in section 9.4-9.9 of the articles of the IHTSDO.

About half of the 12 members of each Standing Committee serve terms that expire in December 2012. People elected to these slots will serve for 2 years (Jan. 2013-December 2014). There may be additional Committee vacancies caused by resignation. The chosen people to fill these slots will serve intermediate for 1 year (Jan-Dec 2013).

Whose terms are expiring the members of the Committee are eligible for quit the Committee itself, provided they have served more than six consecutive years of the Committee of the regions.  Quit the Committee itself is possible after sitting out a minimum of one year from the date on which that have left the Committee.  There is no impediment to a Committee member leaving a Committee and being appointed to another.  Eligible for quit the Committee members must submit a nomination package (see details below).

As A result of changes made to articles approved in April 2009 IHTSDO, most positions on each Committee is at-large seats and can be filled by people appointed by IHTSDO members from any geographical region.  Currently the region the Americas includes the United States and Canada.

Procedure for appointment of United States: All United States affiliate licensees SYSTEMATIZED NOMENCLATURE of MEDICINE CT (aka, all United States UMLS licensees) can vote to select candidates U.S. IHTSDO committees. Is the timeline for the nominations and elections:

4 June – 29 June: NLM accepts nominations of potential candidates for the four permanent committees of IHTSDO. Will be only accepted applicants with complete nomination packages (see below for details and the necessary forms). 16 July – 17 August: U.S. SYSTEMATIZED NOMENCLATURE of MEDICINE CT Affiliates cast votes for candidates for top three for each Standing Committee. Instructions for casting ballots will be sent to U.S. affiliates the SYSTEMATIZED NOMENCLATURE of MEDICINE CT 16 July. For each Committee, the three candidates receiving the most votes will become U.S. candidates for the Committee. 1 September 2012: NLM will submit the names of three candidates 3 receives the most votes as candidates for each of the four committees of IHTSDO for consideration by the General Assembly of the IHTSDO. 22-26 October 2012: IHTSDO will announce the final results of the election process in the General Assembly to be held in conjunction with the community of practice meeting of IHTSDO.

Obligations and participation Committee logistics: English is the official language of IHTSDO, but Commission members must be willing to take additional measures to ensure understanding by those for whom English is a second language. Teleconference agreements are available for all meetings of the Committee, but, given the geographical distribution of IHTSDO members (currently Australia, Canada, Cyprus, Denmark, Estonia, Iceland, Israel, Lithuania, Malta, New Zealand, Poland, Singapore, Slovak Republic, Slovenia, Spain, Sweden, Netherlands, United Kingdom and United States), meeting timetables may not be affordable to all relevant zones. The IHTSDO encourages the members of the Committee to participate in at least one of the two main meetings annually in person IHTSDO. For the members of the Committee of the United States that need assistance to face-to-face meetings, NLM will travel to a meeting of IHTSDO per year. Committee members should participate (in person or via teleconference) at least 50% of their Committee meetings to keep their seat on the Committee. Members of the Committee of the United States may be called upon to provide input and advice on issues relating to the NLM IHTSDO and SYSTEMATIZED NOMENCLATURE of MEDICINE CT.

Submit your application: Nominations are due to NLM by COB June 29, 2012. Please send nomination packages to NLM via email (nichsr@nlm.nih.gov) with the subject line "We nominated – IHTSDO standing committees". Each nomination package must include:

Nomination form (PDF, Word) completed 1 page mini curriculum vitae highlighting the key sectors of the candidate's experience and expertise page 1 Declaration of interest outlining why the candidate is suitable for the particular Board in question and because the candidate feels that the Committee's work are important. Note: applications must be for a specific Commission. Completed an array of skills for the competent Committee that summarizes key aspects of the proposed background content (PDF, Word) quality assurance (PDF, Word) implementation and innovation (PDF, Word) technical (PDF, Word) completed Declaration of interest (PDF, Word)

Individuals may nominate themselves. Questions about the application process should be sent to nichsr@nlm.nih.gov, please include the subject line "We nominated – IHTSDO standing committees".


View the original article here

Linde is an excursion of 1.5 billion euros to cap Lincare buy

Frankfurt am Main, 2 July | Monday July 2, 2012 3:40 am EDT

Frankfurt, July 2 (Reuters)-German industrial gases producer Linde AG plans to increase the capital up to 1.50 billion euros ($ 1.90 billion) to finance the planned acquisition of Lincare Holdings Inc. to become the world's largest provider of medical gases.

Linde said late Sunday agreed to pay $4,60 billion for Florida-based service provider of oxygen and respiratory therapy to patients at home, funded with available cash and a loan of $ 4.50 billion acquisition.

"The acquisition loan will be refinanced through equity issuances to 1.50 billion and debt capital markets," Linde said Monday.

Linde shares extended losses and decreased 4.8% to Euro 116.75 0731 GMT.

Linde added that it was committed to maintaining its current credit ratings, which are "A" by Standard and poor's and "A3" by Moody 's.


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MedlinePlus: shortness of breath

The first row in the table of contents contains the following groups: learn more & Multimedia. Reference materials of PRA

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MedlinePlus: shortness of breath

The first row in the table of contents contains the following groups: learn more & Multimedia. Reference materials of PRA

View the original article here

MedlinePlus: diabetic Cardiopathy

The top row of the table of contents box contains the following groups: learn the basics, more information and Multimedia Tools & Cool. For the Multimedia Group & Cool Tools

View the original article here

MedlinePlus: diabetic Cardiopathy

The top row of the table of contents box contains the following groups: learn the basics, more information and Multimedia Tools & Cool. For the Multimedia Group & Cool Tools

View the original article here

Watch Your Head

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NLM & National Endowment for the Humanities to collaborate on initiatives of common interest

The National Library of Medicine (NLM), largest medical library in the world and a component of the National Institutes of Health and the National Endowment for Humanities (NEH) are forming a new partnership. They will cooperate to develop initiatives which bring together scholars, researchers, librarians, doctors and professionals in the cultural heritage from the biomedical Humanities and community in order to share expertise and develop new research programs.

Representatives of the NLM and the NEH signed a memorandum of understanding outlining their partnership and recognize their shared interest to advance health and the spread of education, training and medical information for research, teaching and learning sciences and biomedical communities.

As initial efforts, the partners will work together to:

Explore areas of mutual interest in research, particularly in the fields of digital humanities and history of medicine; develop and participate in programs and courses, training and opportunities for internships and other educational initiatives; andDevelop initiatives to improve access to careers in medicine and health, with particular interest in reaching students who are underrepresented in the fields

On the partner institutions:

The National Endowment for the Humanities is a grant-making agency-Executive, independent of the United States of America, dedicated to supporting research, education, preservation, and public programs in the humanities and social sciences that use humanistic methods. NEH accomplishes this mission by providing grants for Humanities projects of high quality cultural institutions such as museums, archives, libraries, schools, universities, public television and radio stations and individual scholars.

Since its founding in 1836, the National Library of Medicine has played a key role in translating biomedical research into practice. NLM, the National Institutes of Health, is the largest medical library in the world, with more than 17 million items in the collection. Leader in innovation of information, is the developer of electronic information services used by scientists, health professionals and audiences around the world. NLM makes its services information known and available with the help of the national network of libraries of medicine, which consists of 5,600 member institutions, including eight regional medical libraries. NLM conducts and supports research that relates to computer and information technology to meet the information needs of doctors, public health administrators, biomedical researchers and consumers.

NLM Logo

National Endowment for the Humanities Logo

###


View the original article here

NLM & National Endowment for the Humanities to collaborate on initiatives of common interest

The National Library of Medicine (NLM), largest medical library in the world and a component of the National Institutes of Health and the National Endowment for Humanities (NEH) are forming a new partnership. They will cooperate to develop initiatives which bring together scholars, researchers, librarians, doctors and professionals in the cultural heritage from the biomedical Humanities and community in order to share expertise and develop new research programs.

Representatives of the NLM and the NEH signed a memorandum of understanding outlining their partnership and recognize their shared interest to advance health and the spread of education, training and medical information for research, teaching and learning sciences and biomedical communities.

As initial efforts, the partners will work together to:

Explore areas of mutual interest in research, particularly in the fields of digital humanities and history of medicine; develop and participate in programs and courses, training and opportunities for internships and other educational initiatives; andDevelop initiatives to improve access to careers in medicine and health, with particular interest in reaching students who are underrepresented in the fields

On the partner institutions:

The National Endowment for the Humanities is a grant-making agency-Executive, independent of the United States of America, dedicated to supporting research, education, preservation, and public programs in the humanities and social sciences that use humanistic methods. NEH accomplishes this mission by providing grants for Humanities projects of high quality cultural institutions such as museums, archives, libraries, schools, universities, public television and radio stations and individual scholars.

Since its founding in 1836, the National Library of Medicine has played a key role in translating biomedical research into practice. NLM, the National Institutes of Health, is the largest medical library in the world, with more than 17 million items in the collection. Leader in innovation of information, is the developer of electronic information services used by scientists, health professionals and audiences around the world. NLM makes its services information known and available with the help of the national network of libraries of medicine, which consists of 5,600 member institutions, including eight regional medical libraries. NLM conducts and supports research that relates to computer and information technology to meet the information needs of doctors, public health administrators, biomedical researchers and consumers.

NLM Logo

National Endowment for the Humanities Logo

###


View the original article here

You Can Quit Smoking

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April 6, 2012 / Vol. 61 / No. RR–2


View the original article here

NLM Announces public release of papers of John b. Calhoun, NIH researcher noted social crowding and aggression

The history of Medicine Division, national library of Medicine (NLM) announces the public release of documents from John b. Calhoun (1917-1995), a researcher of behavioral sciences noted at the National Institute of Mental Health (NIMH), a component of the National Institutes of Health. From the 1950s through the 1980s, Dr. Calhoun has studied the behavior of mice and rats in conditions of extreme overcrowding. He, along with other social scientists, politicians and pundits, readily extrapolated his work to comment on Human crowding in urban environments, just as the country was undergoing a massive redevelopment of its urban structures. His conclusions have found a ready audience among those who saw the world's overpopulation as not only a problem of resources, but of social cohesion.

In a statement, Calhoun's work with rats inspired 1971 children's book, Mrs. Frisby and the rats of NIMH by Robert c. O'Brien, which was adapted into an animated film of 1982, the secret of NIMH.

John b. Calhoun was born in Elkton, Tennessee, in 1917. After his undergraduate education at the University of Virginia (B.A., 1939) and postgraduate work in zoology from Northwestern University (PhD, 1943), post-graduate work and Professor at Emory University, Ohio State University and the Johns Hopkins University School of hygiene and public health, studying sociology and ecology of Norway rats. After further work at the Jackson Memorial Laboratory, Bar Harbor, Maine and the army Graduate School at Walter Reed Army Medical Center, in 1954 he joined the section on perception in psychology laboratory at NIMH. He spent the rest of his career.

Study rats in conditions of overcrowding, Calhoun observed what he termed the "behavioural sink". This aberrant behavior as indicated hyperaggression, inability to reproduce normally, infant cannibalism, increased mortality and aberrant sexual models in such situations of overcrowding. His general conclusion was that "the space itself is a necessity". In the 1960s, his research switched in the field of evolution and behavior, which informs the current field of evolutionary psychology. In 1963 he formed and was the first Director of the NIMH for behavioral systems research (URBS) in the laboratory of brain evolution and behavior (LBEB). There he observed the effects of crowding on a community of mice that have been permitted to overpopulate, seeing a complete end to play, with the entire population died. Calhoun coined the term "Autism" to describe the behavior of the Group at that point finale, how I became incapable of social interaction is essential for survival. In the mid-1970s, his research moved to turn to cultural ways that rats acquired to counteract the effects of overcrowding.

Calhoun retired from NIMH in 1984, but continued to work on his research results until his death on September 7, 1995.

The collection, "MS C 586," comprises 196 linear metres of records mostly material from 1954 to 1986. It was donated in 1997, as a gift from Edith Calhoun, his widow. In addition to laboratory notebooks and drafts of articles, the collection is particularly noteworthy for the film, video cassettes and spools audiocassettes that Dr. Calhoun used to document his experiments.

Calhoun cards form one of the collections of research described almost 600 of modern manuscripts of the library program. I am one of a vast number of human development and behavioral sciences; others include the papers of Bertram Brown, Wayne Dennis, Lawrence k. Frank, Paul MacLean, Lois Meek, Lois b. Murphy and Herbert Rowell Stolz, as well as the records of the Society for Research in Child Development and Child Guidance Clinic and child psychiatry movement interview collection.

Calhoun materials can be found in the history of Medicine Division reading room, National Library of Medicine, open Monday to Friday, from 17: 8:30 to 0, except for Federal holidays on the first floor of the building on 38 NIH campus, Bethesda, Maryland. No appointment is necessary. Finding aid for the collection can be found at http://oculus.nlm.nih.gov/cgi/f/findaid/findaid-idx?c=nlmfindaid;idno=calhoun586.

The National Library of Medicine, the largest medical library in the world, is a component of the National Institutes of Health.

Dr. John B. Calhoun points to two tail-wounded mice on his arm from universe 17, study 102. November, 1969.

Dr. John b. Calhoun points to two injured mice tail on her arm from Universe 17, 102. November 1969.

A view of mouse universe 33, showing four cells of group 01 during week 162 of an experiment, possibly study 133. C.1975.

A view of the universe mouse 33, showing four group cells 01 week 162 of an experiment, study possibly 133. C. 1975.


View the original article here

NLM Announces public release of papers of John b. Calhoun, NIH researcher noted social crowding and aggression

The history of Medicine Division, national library of Medicine (NLM) announces the public release of documents from John b. Calhoun (1917-1995), a researcher of behavioral sciences noted at the National Institute of Mental Health (NIMH), a component of the National Institutes of Health. From the 1950s through the 1980s, Dr. Calhoun has studied the behavior of mice and rats in conditions of extreme overcrowding. He, along with other social scientists, politicians and pundits, readily extrapolated his work to comment on Human crowding in urban environments, just as the country was undergoing a massive redevelopment of its urban structures. His conclusions have found a ready audience among those who saw the world's overpopulation as not only a problem of resources, but of social cohesion.

In a statement, Calhoun's work with rats inspired 1971 children's book, Mrs. Frisby and the rats of NIMH by Robert c. O'Brien, which was adapted into an animated film of 1982, the secret of NIMH.

John b. Calhoun was born in Elkton, Tennessee, in 1917. After his undergraduate education at the University of Virginia (B.A., 1939) and postgraduate work in zoology from Northwestern University (PhD, 1943), post-graduate work and Professor at Emory University, Ohio State University and the Johns Hopkins University School of hygiene and public health, studying sociology and ecology of Norway rats. After further work at the Jackson Memorial Laboratory, Bar Harbor, Maine and the army Graduate School at Walter Reed Army Medical Center, in 1954 he joined the section on perception in psychology laboratory at NIMH. He spent the rest of his career.

Study rats in conditions of overcrowding, Calhoun observed what he termed the "behavioural sink". This aberrant behavior as indicated hyperaggression, inability to reproduce normally, infant cannibalism, increased mortality and aberrant sexual models in such situations of overcrowding. His general conclusion was that "the space itself is a necessity". In the 1960s, his research switched in the field of evolution and behavior, which informs the current field of evolutionary psychology. In 1963 he formed and was the first Director of the NIMH for behavioral systems research (URBS) in the laboratory of brain evolution and behavior (LBEB). There he observed the effects of crowding on a community of mice that have been permitted to overpopulate, seeing a complete end to play, with the entire population died. Calhoun coined the term "Autism" to describe the behavior of the Group at that point finale, how I became incapable of social interaction is essential for survival. In the mid-1970s, his research moved to turn to cultural ways that rats acquired to counteract the effects of overcrowding.

Calhoun retired from NIMH in 1984, but continued to work on his research results until his death on September 7, 1995.

The collection, "MS C 586," comprises 196 linear metres of records mostly material from 1954 to 1986. It was donated in 1997, as a gift from Edith Calhoun, his widow. In addition to laboratory notebooks and drafts of articles, the collection is particularly noteworthy for the film, video cassettes and spools audiocassettes that Dr. Calhoun used to document his experiments.

Calhoun cards form one of the collections of research described almost 600 of modern manuscripts of the library program. I am one of a vast number of human development and behavioral sciences; others include the papers of Bertram Brown, Wayne Dennis, Lawrence k. Frank, Paul MacLean, Lois Meek, Lois b. Murphy and Herbert Rowell Stolz, as well as the records of the Society for Research in Child Development and Child Guidance Clinic and child psychiatry movement interview collection.

Calhoun materials can be found in the history of Medicine Division reading room, National Library of Medicine, open Monday to Friday, from 17: 8:30 to 0, except for Federal holidays on the first floor of the building on 38 NIH campus, Bethesda, Maryland. No appointment is necessary. Finding aid for the collection can be found at http://oculus.nlm.nih.gov/cgi/f/findaid/findaid-idx?c=nlmfindaid;idno=calhoun586.

The National Library of Medicine, the largest medical library in the world, is a component of the National Institutes of Health.

Dr. John B. Calhoun points to two tail-wounded mice on his arm from universe 17, study 102. November, 1969.

Dr. John b. Calhoun points to two injured mice tail on her arm from Universe 17, 102. November 1969.

A view of mouse universe 33, showing four cells of group 01 during week 162 of an experiment, possibly study 133. C.1975.

A view of the universe mouse 33, showing four group cells 01 week 162 of an experiment, study possibly 133. C. 1975.


View the original article here

Keep Your Guard Up

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April 6, 2012 / Vol. 61 / No. RR–2
Good Laboratory Practices for Biochemical Genetic Testing and Newborn Screening for Inherited Metabolic Disorders
CE Available

This report provides recommendations for good laboratory practices for biochemical genetic testing and newborn screening for inherited metabolic disorders. The recommended practices address the benefits of using a quality management system approach, factors to consider before introducing new tests, establishment and verification of test performance specifications, the total laboratory testing process, confidentiality of patient information and test results, and personnel qualifications and responsibilities for laboratory testing for inherited metabolic diseases. These recommendations are intended for laboratories that perform biochemical genetic testing to improve the quality of laboratory services and for newborn screening laboratories to ensure the quality of laboratory practices for inherited metabolic disorders. These recommendations also are intended as a resource for medical and public health professionals who evaluate laboratory practices, for users of laboratory services to facilitate their collaboration with newborn screening systems and use of biochemical genetic tests, and for standard-setting organizations and professional societies in developing future laboratory quality standards and practice recommendations.


View the original article here

New topic on Genetics Home Reference: Senior-Løken syndrome

Senior syndrome – ken is a rare condition characterized by the combination of two specific functions: a kidney condition called nephronophthisis and ocular disease known as congenital Leber amaurosis.

Nephronophthisis causes fluid-filled cysts develop in the kidneys begin during childhood. These cysts affect kidney function, initially causing increased urine production (polyuria) and excessive thirst (polydipsia), general weakness and extreme tiredness (fatigue). Nephronophthisis leading to end-terminal chronic renal failure (ESRD) later in childhood or adolescence. ESRD is a life-threatening renal function insufficiency occurs when the kidneys are no longer able to filter efficiently liquids and waste products from the body.

Amaurosis congenita of Leber mainly affects the retina, that is the specialized tissue in the back of the eye that senses light and color. This condition causes vision problems, including an increased sensitivity to light (photophobia), involuntary eye movements (nystagmus) and extreme farsightedness (hyperopia). Some people with the syndrome of Senior-L ken develop signs of congenital Leber amaurosis within the first few years of life, while others do not develop vision problems until later in childhood.

These resources address the diagnosis or management of Senior-L ken and may include providers of treatment.

You may also find information about the diagnosis or management of Senior-L ken in patient support and educational resources.

To locate a healthcare provider, see how do I find a genetics professional in my area? in the manual.

The following resources on Senior syndrome-L ken may be useful. These materials are written for the general public.

You may also be interested in these resources, which are designed for health professionals and researchers.

This manual provides basic information on genetics in clear language.

These links provide additional resources that may be useful to genetics.

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a genetic disease, syndrome or condition should consult with a qualified healthcare provider. See how do I find a genetics professional in my area? in the manual.


View the original article here

New topic on Genetics Home Reference: Senior-Løken syndrome

Senior syndrome – ken is a rare condition characterized by the combination of two specific functions: a kidney condition called nephronophthisis and ocular disease known as congenital Leber amaurosis.

Nephronophthisis causes fluid-filled cysts develop in the kidneys begin during childhood. These cysts affect kidney function, initially causing increased urine production (polyuria) and excessive thirst (polydipsia), general weakness and extreme tiredness (fatigue). Nephronophthisis leading to end-terminal chronic renal failure (ESRD) later in childhood or adolescence. ESRD is a life-threatening renal function insufficiency occurs when the kidneys are no longer able to filter efficiently liquids and waste products from the body.

Amaurosis congenita of Leber mainly affects the retina, that is the specialized tissue in the back of the eye that senses light and color. This condition causes vision problems, including an increased sensitivity to light (photophobia), involuntary eye movements (nystagmus) and extreme farsightedness (hyperopia). Some people with the syndrome of Senior-L ken develop signs of congenital Leber amaurosis within the first few years of life, while others do not develop vision problems until later in childhood.

These resources address the diagnosis or management of Senior-L ken and may include providers of treatment.

You may also find information about the diagnosis or management of Senior-L ken in patient support and educational resources.

To locate a healthcare provider, see how do I find a genetics professional in my area? in the manual.

The following resources on Senior syndrome-L ken may be useful. These materials are written for the general public.

You may also be interested in these resources, which are designed for health professionals and researchers.

This manual provides basic information on genetics in clear language.

These links provide additional resources that may be useful to genetics.

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a genetic disease, syndrome or condition should consult with a qualified healthcare provider. See how do I find a genetics professional in my area? in the manual.


View the original article here

Catch Cancer Early

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AppId is over the quota

April 6, 2012 / Vol. 61 / No. RR–2
Good Laboratory Practices for Biochemical Genetic Testing and Newborn Screening for Inherited Metabolic Disorders
CE Available

This report provides recommendations for good laboratory practices for biochemical genetic testing and newborn screening for inherited metabolic disorders. The recommended practices address the benefits of using a quality management system approach, factors to consider before introducing new tests, establishment and verification of test performance specifications, the total laboratory testing process, confidentiality of patient information and test results, and personnel qualifications and responsibilities for laboratory testing for inherited metabolic diseases. These recommendations are intended for laboratories that perform biochemical genetic testing to improve the quality of laboratory services and for newborn screening laboratories to ensure the quality of laboratory practices for inherited metabolic disorders. These recommendations also are intended as a resource for medical and public health professionals who evaluate laboratory practices, for users of laboratory services to facilitate their collaboration with newborn screening systems and use of biochemical genetic tests, and for standard-setting organizations and professional societies in developing future laboratory quality standards and practice recommendations.


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